关于小儿脾胃疾病相关方剂配伍规律的文献研究

Literature Study on Compatibility of Prescriptions Related to Spleen and Stomach Diseases in Children

目的 运用数据挖掘方法对近年来关于小儿脾胃疾病的相关研究进行研究分析,以揭示治疗小儿脾胃疾病的选方用药及其方剂配伍规律。方法 通过文献检索从中国知网数据库查找近两年来治疗小儿脾胃疾病的相关文献,筛选符合纳入标准的文献运用频次分析、关联规则分析、因子分析等数据挖掘方法进行数据分析。结果 小儿脾胃疾病主要证型分布有脾胃虚弱、脾胃湿热、脾胃虚寒、乳食积滞。主要选用方剂频次使用前五的依次为四君子汤、参苓白术散、藿香正气散、异功散、保和丸。主要用药有白术、甘草、茯苓、陈皮、半夏、山楂、薏苡仁、桔梗、神曲、藿香、山药、厚朴、白扁豆、麦芽、大腹皮、砂仁、白芷、鸡内金、黄芪、人参。方剂配伍高频药对有白术—茯苓、白术—山楂、山楂—鸡内金、陈皮—白术、白术—人参,半夏—厚朴、山药—薏苡仁、藿香—茯苓、砂仁—鸡内金、山药—茯苓、陈皮—山楂。使用因子分析发现高频药组有茯苓—人参—白术—甘草,山药—薏苡仁—山楂—神曲—麦芽,陈皮—半夏—厚朴—砂仁—鸡内金。结论 临床关于小儿脾胃疾病的治疗主要从脾胃虚弱、脾胃湿热、脾胃虚寒、乳食积滞几大证型辨证论治,遣方用药则以补虚、化湿、消食为主,多运用补气剂、祛湿剂以及消食剂加减以治之,以达补益脾胃功能,健脾助运、燥湿和胃、消食化积之效。

Objective The data mining method is used to study and analyze the relevant research on children's spleen and stom-ach diseases in recent years,so as to reveal the selection of drugs and the compatibility of prescriptions for children's spleen and stomach diseases.Methods Through literature search,it searched the relevant literature on the treatment of children's spleen and stomach diseases in the past two years from the database of CNKI,and screened the literature that met the inclusion criteria.Data mining methods such as frequency analysis,association rule analysis and factor analysis were used for data analysis.Results The main syndrome types of children's spleen and stomach diseases are deficiency of spleen and stomach,damp-heat in spleen and stomach,deficiency cold of spleen and stomach and infantile dyspeptic gastroenteropathy.The five most frequently used prescrip-tions are Sijunzi Decoction(四君子汤),Shenling Baizhu Powder(参苓白术散),Huoxiang Zhengqi Powder(藿香正气散),Yigong Powder(异功散)and Baohe Pill(保和丸).The main drugs used include Baizhu(Atractylodis Macrocephalae Rhizo-ma),Gancao(Glycyrrhizae Radix Et Rhizoma),Fuling(Poria),Chenpi(Citri Reticulatae Pericarpium),Banxia(Pinelliae Rhizo-ma),Shanzha(Crataegi Fructus),Yiyiren(Coicis Semen),Jiegeng(Platycodonis Radix),Shenqu(Massa Medicata Fermentata),Huoxiang(Pogostemonis Herba),Shanyao(Dioscoreae Rhizoma),Houpo(Magnoliae Officinalis Cortex),Baibiandou(Lablab Se-men Album),Maiya(Hordei Fructus Germinatus),Dafupi(Arecae Pericarpium),Sharen(Amomi Fructus),Baizhi(Angelicae Dahuricae Radix),Jineijin(Galli Gigerii Endothelium Corneum),Huangqi(Astragali Radix)and Renshen(Ginseng Radix Et Rhizoma).Prescription compatibility high-frequency drug pairs include Baizhu(Atractylodis Macrocephalae Rhizoma)-Fuling(Poria),Baizhu(Atractylodis Macrocephalae Rhizoma)-Shanzha(Crataegi Fructus),Shanzha(Crataegi Fructus)-Jineijin(Galli Gigerii Endothelium Corneum),Chenpi(Citri Reticulatae Pericarpium)-Baizhu(Atractylodis Macrocephalae Rhizoma),Baizhu(Atractylodis Macrocephalae Rhizoma)-Renshen(Ginseng Radix Et Rhizoma),Banxia(Pinelliae Rhizoma)-Houpo(Magnoliae Officinalis Cortex),Shanyao(Dioscoreae Rhizoma)-Yiyiren(Coicis Semen),Huoxiang(Pogostemonis Herba)-Fuling(Poria),Sharen(Amomi Fructus)-Jineijin(Galli Gigerii Endothelium Corneum),Shanyao(Dioscoreae Rhizoma)-Ful-ing(Poria),Chenpi(Citri Reticulatae Pericarpium)-Shanzha(Crataegi Fructus).Using factor analysis,it was found that the high-frequency drug group include Fuling(Poria)-Renshen(Ginseng Radix Et Rhizoma)-Baizhu(Atractylodis Macrocepha-lae Rhizoma)-Gancao(Glycyrrhizae Radix Et Rhizoma),Shanyao(Dioscoreae Rhizoma)-Yiyiren(Coicis Semen)-Shanzha(Crataegi Fructus)-Shenqu(Massa Medicata Fermentata)-Maiya(Hordei Fructus Germinatus),Chenpi(Citri Reticulatae Peri-carpium)-Banxia(Pinelliae Rhizoma)-Houpo(Magnoliae Officinalis Cortex)-Sharen(Amomi Fructus)-Jineijin(Galli Gige-rii Endothelium Corneum).Conclusion The clinical treatment of children's spleen and stomach diseases is mainly based on the syndrome differentiation and treatment of deficiency of spleen and stomach,damp-heat in spleen and stomach,deficiency cold of spleen and stomach and infantile dyspeptic gastroenteropathy.The treatment is mainly to tonify deficiency,resolve dampness and digest food.The prescriptions for tonifying Qi,resolving dampness and digesting food are used so as to achieve the effect of re-plenishing and benefiting spleen and stomach function,strengthening spleen and helping the transportation,drying dampness and harmonizing stomach and digesting the accumulation.