地黄山药胶囊辅助降血糖临床效果观察

Clinical observation on the adjuvant hypoglycemic effect of rehmanniae radix and yam capsule

目的 观察地黄山药胶囊降糖效果。方法 选择110例符合纳入标准的2型糖尿病患者,按受试者的血糖水平随机分为试食组与对照组,观察服用地黄山药胶囊60 d后对患者空腹血糖和餐后2 h血糖的影响及临床症状改善情况。结果 试食组试验前后空腹血糖值分别为(7.59±2.69)和(5.74±1.74)mmol/L,餐后2 h血糖值为(13.02±4.03)和(7.98±2.25)mmol/L。和对照组比较,试食组空腹血糖和餐后2 h血糖均下降(t值分别为2.496、2.609,P均<0.05),试食组空腹血糖下降百分率为24.37%,餐后2 h血糖下降百分率为38.71%;试食组空腹血糖及餐后2 h血糖自身前后比较差异有统计学意义(t值分别为5.007、9.430,P<0.05)。试食组糖化血红蛋白、总胆固醇和甘油三酯试验后分别为(5.69±1.11)%、(4.90±0.92)mmol/L、(1.59±0.70)mmol/L,均出现下降,自身前后比较差异有统计学意义(t值分别为4.698、3.462、3.196,P均<0.05);试食组口渴多饮、多食易饥、倦怠乏力、多尿等主要临床症状改善,临床症状积分(2.12±1.71)分和对照组(2.88±1.64)分比较,差异有统计学意义(t=2.270,P<0.05)。结论 地黄山药胶囊有辅助降血糖作用。

Objective To observe hypoglycemic effect of rehmanniae radix and yam capsule. Methods In total, 110 patients with type 2 diabetes mellitus who met inclusion criteria were recruited and randomly divided into trial group and control group according to their blood sugar levels. The effect on fasting blood glucose(FBG) and 2-hour postprandial blood glucose(2 hPBG),and the improvement of clinical symptoms were observed after taking rehmanniae radix and yam capsule for 60 days. Results The FBG values before and after the experiment in trial group were(7.59±2.69) mmol/L and(5.74±1.74) mmol/L, and the 2 hPBG values were(13.02±4.03) mmol/L and(7.98±2.25) mmol/L, respectively. The FBG and 2 h PBG levels in the trial group both decreased significantly compared to control group(t=2.496, 2.609, both P<0.05), with a declining rate of 24.37% and 38.71%,respectively. There were statistically significant differences in FBG and 2 h PBG between before and after the experiment in trial group(t=5.007, 9.430, both P<0.05). The levels of glycated hemoglobin, total cholesterol, and triglycerides in trial group were(5.69±1.11)%,(4.90±0.92) mmol/L, and(1.59±0.70) mmol/L, all showing a decrease after the experiment, and the differences between before and after the experiment were statistically significant(t =4.698, 3.462, 3.196, all P <0.05). The main clinical symptoms including polydipsia, bulimia, asthenia, and polyuria in trial group were improved, and the clinical symptom score showed a statistically significant difference compared to control group [(2.12±1.71) vs(2.88±1.64), t=2.270, P<0.05)]. Conclusions Rehmanniae radix and yam capsule can help reduce blood sugar.