摘要
厚朴药材具有止咳祛痰作用,对气管平滑肌具有收缩和舒张的双向作用。厚朴酚及和厚朴酚是疏水性烯丙基联苯酚类结构的同分异构体,也是厚朴产生呼吸系统药理作用的主要活性成分。厚朴酚及和厚朴酚都具有松弛气管平滑肌作用和平喘作用,都具有肺保护作用和对抗各种病理因子引起的肺损伤作用。厚朴酚及和厚朴酚还具有广谱的抗病毒、抗菌和细胞保护作用,尤其适用于具有基础疾病的各种肺损伤,以期被开发为新药供临床利用。
Magnoliae Officinalis Cortex has antitussive and expectorant effects,and dual-directional action on contraction and relaxation of bronchial smooth muscle.Magnolol and honokiol are hydrophotic isomer of propenyl biphenol-type structure,and major active components of Magnoliae Officinalis Cortex in pharmacologic action of respiratory system.Magnolol and honokiol have relaxation of trachea smooth muscle and antiasthmatic effect,have lung-protection,and antagonize lung injury induced by various pathological factors.Magnolol and honokiol have broad-spectrum antibacterial and anti-viral effects,and cellular protection,too.Magnolol and honokiol to prevention and treatment for various pneumonia with basic disease were recommended,intended to be developed as a new drug for clinical use.
作者
张明发
沈雅琴
ZHANG Mingfa;SHEN Yaqin(Shanghai Meiyou Pharmaceutical Co.,Ltd.,Shanghai 201204,China)
出处
《药物评价研究》
CAS
北大核心
2024年第4期904-913,共10页
Drug Evaluation Research
关键词
厚朴
厚朴酚
和厚朴酚
呼吸系统疾病
平喘
肺保护
Magnoliae Officinalis Cortex
magnolol
honokiol
respiratory disease
antiasthma
lung protection