厚朴提取物及其有效成分的呼吸系统药理作用研究进展

Research advances on pharmacologic effects in respiratory system of extract,magnolol and honokiol from Magnoliae Officinalis Cortex

厚朴药材具有止咳祛痰作用,对气管平滑肌具有收缩和舒张的双向作用。厚朴酚及和厚朴酚是疏水性烯丙基联苯酚类结构的同分异构体,也是厚朴产生呼吸系统药理作用的主要活性成分。厚朴酚及和厚朴酚都具有松弛气管平滑肌作用和平喘作用,都具有肺保护作用和对抗各种病理因子引起的肺损伤作用。厚朴酚及和厚朴酚还具有广谱的抗病毒、抗菌和细胞保护作用,尤其适用于具有基础疾病的各种肺损伤,以期被开发为新药供临床利用。

Magnoliae Officinalis Cortex has antitussive and expectorant effects,and dual-directional action on contraction and relaxation of bronchial smooth muscle.Magnolol and honokiol are hydrophotic isomer of propenyl biphenol-type structure,and major active components of Magnoliae Officinalis Cortex in pharmacologic action of respiratory system.Magnolol and honokiol have relaxation of trachea smooth muscle and antiasthmatic effect,have lung-protection,and antagonize lung injury induced by various pathological factors.Magnolol and honokiol have broad-spectrum antibacterial and anti-viral effects,and cellular protection,too.Magnolol and honokiol to prevention and treatment for various pneumonia with basic disease were recommended,intended to be developed as a new drug for clinical use.