拉贝洛尔治疗妊娠高血压的临床应用价值

Clinical Application Value of Labetalol in the Treatment of Pregnancy induced Hypertension

目的分析妊娠高血压引入拉贝洛尔用药方案治疗的实践价值。方法选取2021年1月—2023年6月泰州妇产医院妇产科收治的76例妊娠高血压患者为研究对象,按照随机数表法分为两组,各38例,观察组以基础对症用药+拉贝洛尔用药,对照组仅基础对症用药,比较两组血压改善情况、血流流变学与24 h尿蛋白定量指标、不良反应、母婴结局。结果观察组血压改善情况优于对照组,差异有统计学意义(P<0.05)。观察组血流流变学与24 h尿蛋白定量指标低于对照组,差异有统计学意义(P均<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。观察组自然分娩率(84.21%)高于对照组(52.63%),差异有统计学意义(χ^(2)=8.769,P<0.05)。结论在妊娠高血压治疗中,联合拉贝洛尔用药治疗方案,有效性、安全性显著。

Objective To analyze the practical value of introducing labetalol medication regimen in the treatment of pregnancy-induced hypertension.Methods A total of 76 patients with gestational hypertension admitted to the obstetrics and Gynecology Department of Taizhou Obstetrics and Gynecology Hospital from January 2021 to June 2023 were selected as the study objects divided into two groups according to random number table method,with 38 cases in each group.The observation group was treated with basic symptomatic medication+labetalol,while the control group was treated with basic symptomatic medication only.The improvement of blood pressure,blood flow rhedogy and quantitative index of 24 h urinary protein indices of 24-h urinary proteins,adverse reactions and maternal and infant outcomes of the two groups were compared.Results The improvement of blood pressure in the observation group was better than that in the control group,and the difference was statistically significant(P<0.05).The blood flow rhedogy and quantitative index of 24 h urinary protein indices of 24-h urinary proteins in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The natural delivery rate of observation group(84.21%)was higher than that of control group(52.63%),and the difference was statistically significant(χ^(2)=8.769,P<0.05).Conclusion In the treatment of pregnancy-induced hypertension,the combination of labetalol medication regimen is effective and safe.