二甲双胍联合炔雌醇环丙孕酮片治疗青春期月经失调及多囊卵巢综合征的效果及对TC水平的影响

Effect of Metformin Combined with Ethinestradiol Cyproterone Tablets in the Treatment of Adolescent Menstrual Disorders and Polycystic Ovary Syndrome and Its Influence on TC Levels

目的探究二甲双胍与炔雌醇环丙孕酮片综合疗法在优化青春期月经失调及多囊卵巢综合征患者总胆固醇(Total Cholesterol,TC)水平方面产生的积极作用。方法选取2021年7月—2023年6月山东省滕州市妇幼保健院青春期保健科收治的72例青春期月经失调及多囊卵巢综合征患者为研究对象,以奇偶数法分为两组,其中的奇数编号患者纳入对照组(n=36,实施炔雌醇环丙孕酮片单一疗法),偶数编号患者纳入观察组(n=36,实施二甲双胍片与炔雌醇环丙孕酮片综合疗法),比较两组的治疗情况。结果治疗后,观察组胰岛素、血脂以及性激素相关指标优于对照组,差异有统计学意义(P均<0.05)。观察组的不良反应总发生率为5.56%,低于对照组的22.22%,差异有统计学意义(χ^(2)=4.181,P<0.05)。结论青春期月经失调及多囊卵巢综合征患者接受二甲双胍与炔雌醇环丙孕酮片综合疗法的治疗后,可大幅度优化机体的TC水平,异常的胰岛素及性激素水平得以明显恢复,且治疗后不良反应少,安全性佳,临床效果显著。

Objective To explore the positive effect of combined therapy with metformin and ethinestradiol cyproterone tablets on optimizing the level of total cholesterol(TC)in adolescent patients with menstrual disorders and polycystic ovary syndrome.Methods 72 adolescent patients with menstrual disorders and polycystic ovary syndrome admitted to the Adolescent Health Department of Tengzhou Maternal and Child Health Hospital in Shandong Province from July 2021 to June 2023 were selected as the research subjects.They were divided into two groups using odd even numbers method.The odd numbered patients were included in the control group(n=36,receiving monotherapy with ethinestradiol cyproterone tablets),while the even numbered patients were included in the observation group(n=36,receiving combination therapy with metformin tablets and ethinestradiol cyproterone tablets).The treatment outcomes of the two groups were compared.Results After treatment,the insulin,blood lipids,and sex hormone related indicators in the observation group were better than those in the control group,and the differences were statistically significant(all P<0.05).The total incidence of adverse reactions in the observation group was 5.56%,which was lower than the control group's 22.22%,and the difference was statistically significant(χ^(2)=4.181,P<0.05).Conclusion Adolescent patients with menstrual disorders and polycystic ovary syndrome received metformin and ethinestradiol cyproterone tablets combined therapy,the body's TC level has been greatly optimized,abnormal insulin and sex hormone levels can be significantly restored,adverse reactions are less,safety is good,and clinical effects are significant after treatment.