rhBNP与沙库巴曲缬沙坦钠联合治疗对射血分数下降心力衰竭患者心功能及自主神经功能的影响

Effects of rhBNP Combined with Sacubitril Valsartan Sodium on Cardiac Function and Autonomic Nervous Function in Patients with Decreased Ejection Fraction Heart Failure

目的研究分析重组人脑利钠肽(Recombinant Human Brain Natriuretic Peptide,rhBNP)与沙库巴曲缬沙坦钠联合治疗对射血分数下降心力衰竭(Decreased Ejection Fraction Heart Failure,HFrEF)患者心功能及自主神经功能的影响。方法简单随机选取2022年8月—2023年8月漳州市第三医院收治的60例HFrEF患者作为研究对象,采用随机数表法分为两组,各30例。对照组予以沙库巴曲缬沙坦钠单药治疗,观察组予以rhBNP及沙库巴曲缬沙坦钠两药共治,比较两组患者的用药效果。结果观察组临床总有效率(93.33%)高于对照组(73.33%),差异有统计学意义(χ^(2)=4.320,P<0.05)。治疗后,观察组左室射血分数(Left Ventricular Ejection Fraction,LVEF)较对照组更高,左室舒张期后壁厚度(Left Ventricular Diastolic Posterior Wall Thickness,LVPWD)、左室舒张期内径(Left Ventricular Diastolic Diameter,LVEDD)均较对照组更低,差异有统计学意义(P均<0.05)。治疗后,观察组去甲肾上腺素(Norepinephrine,NE)、血管紧张素Ⅱ(AngiotensinⅡ,AngⅡ)及醛固酮水平均低于对照组,差异有统计学意义(P均<0.05)。两组患者不良反应发生率对比,差异无统计学意义(P>0.05)。结论rhBNP与沙库巴曲缬沙坦钠两药共治可提升对HFrEF患者的治疗效果,有效改善其心功能及自主神经功能,且安全可靠。

Objective To study and analyze the effect of recombinant human brain natriuretic peptide(rhBNP)combined with sakubactril valsartan on cardiac function and autonomic nervous function in decreased ejection fraction heart failure(HFrEF)patients.Methods A total of 60 patients with HFrEF admitted to Zhangzhou Third Hospital from August 2022 to August 2023 were simple randomly selected as the study objects and divided into two groups with 30 patients in each group by random number table method.The control group was treated with sacubactril valsartan sodium as a single drug,and the observation group was treated with rhBNP and sacubactril valsartan sodium as a combined drug.The drug effects of the two groups were compared.Results The total clinical effective rate in observation group(93.33%)was higher than that in control group(73.33%),and the difference was statistically significant(χ^(2)=4.320,P<0.05).After treatment,the left ventricular ejection fraction(LVEF)in the observation group was higher than that in the control group,left ventricular diastolic posterior wall thickness(LVPWD)and left ventricular diastolic diameter(LVPWD)were lower than those of control group,and the differences were statistically significant(all P<0.05).After treatment,the levels of norepinephrine(NE),angiotensinⅡ(AngⅡ)and aldosterone in observation group were lower than those in control group,and the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion rhBNP combined with sacubactril valsartan sodium can improve the therapeutic effect of HFrEF patients,improve their heart function and autonomic nervous function more effectively,and it is safe and reliable.