盐酸米诺环素软膏与甲硝唑片联合治疗对牙周炎患者口腔环境的影响及安全性

Effect of Minocycline Hydrochloride Ointment and Metronidazole Tablets on the Oral Environment and Safety of Patients with Periodontitis

目的分析盐酸米诺环素软膏与甲硝唑片联合治疗对牙周炎患者口腔环境的影响及安全性。方法方便选取2021年8月—2023年10月经漳浦县中医院确诊为牙周炎的患者84例作为研究对象,结合随机数表法将其分为两组,每组42例。对照组予以甲硝唑片单药治疗,观察组予以盐酸米诺环素软膏及甲硝唑片联合治疗,对比两组用药疗效、口腔环境、龈沟液炎症情况以及用药安全性。结果观察组用药总有效率(95.24%)高于对照组(80.95%),差异有统计学意义(χ^(2)=4.086,P<0.05)。治疗后,观察组龈沟出血指数、菌斑指数均低于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组各项龈沟液炎症指标检测值均低于对照组,差异有统计学意义(P均<0.05)。两组用药不良反应发生率对比,差异无统计学意义(P>0.05)。结论盐酸米诺环素软膏及甲硝唑片联合治疗可提升对牙周炎的治疗效果,更有效清除龈沟液炎症,改善患者的口腔健康环境,且用药相对安全可靠。

Objective To analyze the effect of minocycline hydrochloride ointment and metronidazole tablets on the oral environment and safety of patients with periodontitis.Methods 84 patients diagnosed with periodontitis by Zhangpu County Hospital of Traditional Chinese Medicine from August 2021 to October 2023 were conveniently selected as study objects and grouped by randomized table method with 42 cases in each group.The control group was treated with metronidazole tablets,and the observation group was treated with minocycline hydrochloride ointment and metronidazole tablets.Compared the efficacy of medication,oral environment,gingival fluid inflammation and safety of medication in the two groups.Results The total effective rate of medication in the observation group(95.24%)was higher than that in the control group(80.95%),and the difference was statistically significant(χ^(2)=4.086,P<0.05).After treatment,the gingival sulcus bleeding index(SBI)and plaque index(PLI)of the observation group were lower than those of the control group,and the differences were statistically significant(both P<0.05).After treatment,the detection values of various gingival sulcus fluid inflammation indexes in the observation group were lower than those in the control group,and the differencs were statistically significant(all P<0.05).The percentage of adverse drug reactions between the two groups was close,and the difference was not statistically significant(P>0.05).Conclusion Minocycline hydrochloride ointment and metronidazole tablets can enhance the therapeutic effect on periodontitis,clear the inflammation of gingival sulcus fluid more effectively,and improve the oral health environment of patients,and the medication is relatively safe and reliable.