血清TXNIP、sTREM-1、BMP-7水平变化与原发性肾病综合征患者疾病转归的关系

Correlation Between Serum TXNIP, sTREM-1 and BMP-7 Levels and Disease Outcome in Patients with Primary Nephrotic Syndrome

目的 探讨血清硫氧还蛋白相互作用蛋白(TXNIP)、可溶性髓系细胞触发受体-1(sTREM-1)、骨形态发生蛋白-7(BMP-7)水平变化与原发性肾病综合征(PNS)患者疾病转归的相关性。方法 选取医院2019年4月至2022年4月收治的91例PNS患者为研究组,同期91例健康体检者为对照组,比较两组入院时血清TXNIP、sTREM-1、BMP-7、肾功能指标[尿素氮(BUN)、血肌酐(Scr)、尿酸(UA)]水平,分析血清各指标水平与肾功能的相关性;比较复发和未复发患者(入院时、治疗3个月、6个月后)血清各指标水平;分析治疗后血清各指标水平联合预测PNS患者复发的价值,分析各指标不同水平患者复发危险度。结果 入院时研究组血清TXNIP、sTREM-1高于对照组,血清BMP-7低于对照组(P<0.05);入院时研究组血清BUN、Scr、UA高于对照组(P<0.05);入院时血清TXNIP、sTREM-1水平与BUN、Scr、UA水平均呈正相关,血清BMP-7水平与BUN、Scr、UA水平均呈负相关(P<0.05);入院时、治疗3个月、6个月后复发患者血清TXNIP、sTREM-1水平高于未复发患者,BMP-7水平低于未复发患者(P<0.05);治疗3、6个月后血清各指标联合预测PNS患者复发价值大于单独预测;治疗3、6个月后血清各指标高水平患者复发危险度是低水平的1.906、2.114、0.581倍/2.571、3.222、0.480倍。结论 血清TXNIP、sTREM-1、BMP-7水平与PNS患者病情程度密切相关,可作为评估PNS病情转归的有效指标。

Objective To investigate the correlation between serum thioredoxin interacting protein(TXNIP),soluble myeloid cell trigger receptor-1(sTREM-1)and bone morphogenetic protein-7(BMP-7)levels and disease outcome in patients with primary nephrotic syndrome(PNS).Methods Ninety-one patients with PNS admitted to the hospital from April 2019 to April 2022 were selected as the study group,and 91 healthy subjects during the same period were selected as the control group.Serum TXNIP,sTREM-1,BMP-7,renal function index[blood urea nitrogen(BUN),serum creatinine(Scr),uric acid(UA)]levels were compared between the two groups at admission.The correlation between serum indexes and renal function was analyzed.Serum levels were compared between patients with and without recurrence(at admission,3 months after treatment,6 months after treatment).After treatment,the combined prediction value of serum index levels in PNS patients was analyzed,and the risk of relapse in patients with different levels of each index was analyzed.Results Serum TXNIP and sTREM-1 in the study group were higher than those in the control group,and serum BMP-7 was lower than those in the control group(P<0.05).Serum BUN,Scr and UA of the study group were higher than those of the control group at admission(P<0.05).At admission,serum TXNIP and sTREM-1 levels were positively correlated with BUN,Scr and UA levels,while serum BMP-7 levels were negatively correlated with BUN,Scr and UA levels(P<0.05).The levels of TXNIP and sTREM-1 in patients with recurrence were higher than those without recurrence at admission,3 months and 6 months after treatment,and the levels of BMP-7 were lower than those without recurrence(P<0.05).After 3 and 6 months of treatment,the combined value of serum indexes in predicting the recurrence of PNS patients was greater than that of single prediction.After 3 and 6 months of treatment,the risk of relapse in patients with high serum levels was 1.906,2.114,0.581 times and 2.571,3.222,0.480 times of that with low levels.Conclusion Serum TXNIP,sTREM-1 and BMP-7 levels are closely related to the severity of PNS patients,and can be used as effective indicators to evaluate the outcome of PNS.