间苯三酚与山莨菪碱在急诊肾绞痛患者中的应用效果比较

Comparison of the application effect of Phloroglucinol and Anisodamine in emergency renal colic patients

目的探讨间苯三酚与山莨菪碱在急诊肾绞痛患者中的应用效果比较。方法选取2022年3月至2023年9月华中科技大学协和深圳医院急诊收治的86例肾绞痛患者作为研究对象,按随机数字表法将其分为对照组(43例)和观察组(43例)。对照组采用双氯芬酸钠缓释片+山莨菪碱治疗,研究组采用双氯芬酸钠缓释片+间苯三酚治疗。比较两组临床疗效、疼痛程度[视觉模拟评分法(VAS)评分]、疼痛缓解时间、镇痛起效时间、不良反应发生率、24 h复发率。结果研究组总有效率高于对照组,差异有统计学意义(P<0.05);研究组治疗后VAS评分低于对照组,差异有统计学意义(P<0.05);研究组疼痛缓解时间、镇痛起效时间均短于对照组,差异有统计学意义(P<0.05);研究组不良反应总发生率低于对照组,差异有统计学意义(P<0.05);研究组24 h复发率低于对照组,差异有统计学意义(P<0.05)。结论间苯三酚作为一种新型解痉止痛药,与山莨菪碱相比起效快,解痉止痛效果显著,且副作用较小,安全性更高,具有临床应用价值。

Objective To explore the comparison of the application effects of Phloroglucinol and Anisodamine in emergency renal colic patients.Methods A total of 86 patients with renal colic admitted to the emergency department of Huazhong University of Science and Technology Shenzhen Hospital from March 2022 to September 2023 were selected as the study subjects.They were divided into control group(43 cases)and observation group(43 cases)by random number table method.The control group was treated with Sustained-Release Diclofenac Sodium Tablets and Anisodamine,while the study group was treated with Sustained-Release Diclofenac Sodium Tablets and Phloroglucinol.The clinical efficacy,pain severity(visual analogue scale[VAS]score),pain relief time,analgesic onset time,incidence of adverse reactions,and 24-hour recurrence rate were compared between two groups.Results The total effective rate of the research group was higher than that of the control group,and the differences was statistically significant(P<0.05).The VAS score of the study group after treatment was lower than that of the control group,and the difference was statistically significant(P<0.05).The pain relief time and analgesic effect time of the research group were shorter than those of the control group,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).The 24-hour recurrence rate in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion As a new type of antispasmodic and analgesic drug,Anisodamine has a faster onset of action,significant antispasmodic and analgesic effects,smaller side effects,higher safety,and clinical application value compared to Anisodamine.