冠心病合并高血压患者血清脂蛋白相关磷脂酶A2变化水平与临床特征及预后相关性分析

Correlation analysis of serum lipoprotein-associated phospholipase A2 with clinical features and prognosis in patients with coronary heart disease combined with hypertension

目的探析冠心病合并高血压的影响因素。方法选取2019年12月至2021年12月在江西省萍乡市人民医院住院治疗的60例冠心病合并高血压患者作为观察组,另选取60例单纯冠心病患者作为对照组,比较两组基本资料及临床资料,分析冠心病合并高血压的危险因素。结果两组职业、文化程度比较,差异无统计学意义(P>0.05);观察组年龄≥65岁、吸烟、脉压>40 mmHg、血清脂蛋白相关磷脂酶A2(Lp-PLA2)>175 ng/ml比例高于对照组,差异有统计学意义(P<0.05)。多因素分析显示,患者年龄≥65岁(β=1.121,OR=4.157,95%CI=2.186~5.499)、吸烟(β=1.341,OR=2.103,95%CI=1.472~3.284)、脉压>40 mmHg(β=1.127,OR=3.861,95%CI=2.049~4.867)、血清Lp-PLA2水平>175 ng/ml(β=1.378,OR=1.984,95%CI=1.453~3.241)均为冠心病合并高血压的独立危险因素(P<0.05)。结论年龄≥65岁、吸烟、脉压>40 mmHg、血清Lp-PLA2水平>175 ng/ml均为冠心病合并高血压的独立危险因素,能为早期无创预测冠心病合并高血压患者的临床特征和预后提供准确的理论依据。

Objective To explore the influencing factors of coronary heart disease complicated with hypertension.Methods A total of 60 patients with coronary heart disease combined with hypertension from December 2019 to December 2021 in Pingxiang People's Hospital were selected as the observation group and 60 patients with simple coronary heart disease were selected as the control group.The basic and clinical data of the two groups were compared to analyze the risk factors of coronary heart disease combined with hypertension.Results There were no significant differences in occupational and educational level between the two groups(P>0.05).The proportion of age≥65 years old,smoking,pulse pressure>40 mmHg and serum lipoprotein-associated phospholipase A2(Lp-PLA2)>175 ng/ml in observation group were higher than those in control group,and the differences were statistically significant(P<0.05).Multivariate analysis showed that patients'age≥65 years old(β=1.121,OR=4.157,95%CI=2.186-5.499),smoking(β=1.341,OR=2.103,95%CI=1.472-3.284),pulse pressure>40 mmHg(β=1.127,OR=3.861,95%CI=2.049-4.867),and serum Lp-PLA2 level>175 ng/ml(β=1.378,OR=1.984,95%CI=1.453-3.241)were independent risk factors for coronary heart disease combined with hypertension(P<0.05).Conclusion Age≥65 years old,smoking,pulse pressure>40 mmHg and serum Lp-PLA2 level>175 ng/ml are independent risk factors of coronary heart disease combined with hypertension,which can provide accurate theoretical basis for early non-invasive prediction of clinical features and prognosis of coronary heart disease combined with hypertension.