烯丙雌醇片联合利托君治疗先兆流产效果及对内分泌指标、症状体征的影响

Effect of Allylestradiol Tablets Combined with Ritodrine in the Treatment of Threatened Abortion and its Influence on Endocrine Indexes,Symptoms and Signs

目的:探讨烯丙雌醇片联合利托君治疗先兆流产效果。方法:选择2023.5月~2023.10月的92例先兆流产患者作为研究对象。将所有患者随机均分为两组(对照组与观察组),对照组行利托君治疗,观察组在对照组基础上加用烯丙雌醇片,对比两组的治疗效果,对比两组的阴道出血、腹痛、宫缩消失时间,对比两组的血清性激素水平、子宫血流状态,对比两组治疗期间的不良反应发生情况及保胎成功率。结果:观察组治疗有效率较对照组高(P<0.05)。观察组的临床症状消失时间明显较低(P<0.05)。治疗前,两组的人绒毛膜促性腺激素水平、孕酮、血清纤维蛋白原水平、子宫动脉搏动指数、血流阻力指数对比无统计学意义(P>0.05);治疗后,两组的人绒毛膜促性腺激素、孕酮水平明显升高,血清纤维蛋白原水平、子宫动脉搏动指数、血流阻力指数明显降低,且观察组变化幅度明显较高(P<0.05)。两组不良反应无统计学意义(P>0.05)。观察组的保胎成功率较对照组高,但组间对比无统计学意义(P>0.05)。结论:烯丙雌醇片联合利托君可明显缩短先兆流产的临床体征改善时间,改善内分泌指标水平及子宫血流状态,提高治疗效果及保胎成功率,且应用较安全,值得临床应用推广应用。

Objective:To investigate the effects of allylestradiol tablets combined with ritodrine in the treatment of threatened abortion and its effects on endocrine indexes,symptoms and signs.Methods:92 patients with threatened abortion ranging from May 2023 to October 2023 were selected as the study subjects.All patients are randomly divided into two groups(control group and observation group),the control group LiTuoJun treatment,observation group on the control of the group with acrylic oestradiol tablets,compare the treatment effect,compare the two groups of vaginal bleeding,abdominal pain,contractions disappear time,compare the two groups of serum hormone levels,uterine blood flow state,compare the two groups of adverse reactions during the treatment of the success rate.Results:The effective rate in the observation group was higher(P<0.05).The disappearance time of abdominal pain,vaginal bleedingand uterine contraction in observation group was significantly lower(P<0.05).After treatment,the levels of human chorionic gonadotropin and progesterone were increased,and the levels of serum fibrinogen,uterine artery pulsation index and blood flow resistance index were significantly decreased in both groups,and the change range of observation group was significantly higher(P<0.05).During treatment,there was no statistical significance in adverse reactions between the two groups(P>0.05).The success rate of the observation group was higher,while there was no statistical significance(P>0.05).Conclusion:Allylestradiol tablets combined with ritodrine can obviously shorten the improvement time of clinical signs of threatened abortion,improve the level of endocrine indicators and uterine blood flow,improve the therapeutic effect and the success rate of fetal protection,and the application is safe,worthy of clinical application and promotion.