心房颤动患者TGF-β1/Smad2、smad7信号通路在心房肌重构表达的研究

Study on the Expression of TGF-β1/Smad2 and Smad7 Signaling Pathways in Atrial Remodeling in Patients with Atrial Fibrillation

目的探讨TGF-β1信号通路中的Smad2、smad7表达分布变化与房颤纤维化的发生、发展的关系。方法选取2018年1月至2020年12月于我院行心脏外科手术患者52例,按病变性质分为房颤组24例(RAF)和窦律组28例(RSR),通过检测心外科手术患者房颤及窦性心律组右心房组织中的Smad2、smad7、纤维化因子Fibronectin的表达,比较Smad2、smad7表达量、空间分布及Fibronectin表达量变化。结果房颤患者右心房Smad2表达量明显高于窦性心律组,而smad7表达量明显低于窦性心律患者,纤维化因子Fibronectin表达量明显高于窦性心律组,差异有统计学意义(P<0.05)。结论TGF-β1/Smad2、smad7信号通路参与房颤心房纤维化所致结构重构。

Objectives To explore TGF-β1 The relationship between the expression and distribution changes of Smad2 and Smad7 in the TGF-β1 signaling pathway and the occurrence and development of atrial fibrillation fibrosis.Methods A total of 52 patients who underwent cardiac surgery in our hospital from January 2018 to December 2020 were selected and divided into two groups based on the nature of the lesion,and there are 24 patients in the atrial fibrillation group(RAF)and 28 patients in the sinus rhythm group(RSR).By detecting the expression of Smad2,Smad7,and fibronectin in the right atrial tissue of patients with atrial fibrillation and sinus rhythm undergoing cardiac surgery,the expression levels,spatial distribution,and changes in fibronectin expression levels of Smad2 and Smad7 were compared.Results The expression of Smad2 in the right atrium of patients with atrial fibrillation was significantly higher than that of patients with sinus rhythm,while the expression of Smad7 was significantly lower than that of patients with sinus rhythm,and the expression level of fibronectin in the fibrosis factor group was significantly higher than that in the sinus rhythm group(P<0.05).Conclusions TGF-β1/Smad2 and Smad7 signaling pathways are involved in structural remodeling caused by atrial fibrosis in atrial fibrillation.