慢阻肺6号方联合穴位贴敷对AECOPD疗效及免疫功能的影响

Effect of Slow Obstructive Pulmonary 6 Formula Combined with Acupoint Application on the Efficacy and Immune Function of AECOPD

目的 探析慢阻肺6号方联合穴位贴敷对急性加重期慢性阻塞性肺疾病(AECOPD)疗效及免疫功能的影响。方法 前瞻性分析,选取2022年1月至2023年6月赣州市中医院收治的AECOPD患者80例作为研究对象,随机数字表法分为治疗组和对照组各40例。对照组给予常规对症处理,治疗组在对照组基础上加用慢阻肺6号方联合穴位贴敷治疗,比较两组临床疗效,免疫功能(T淋巴细胞亚群CD4^(+)、CD8^(+)占比及CD4^(+)/CD8^(+)比值的变化)及不良反应。结果治疗组有效率高于对照组,差异有统计学意义(P<0.05)。经10 d治疗,两组CD4^(+)、CD4^(+)/CD8^(+)均高于治疗前,CD8^(+)低于治疗前,治疗组各指标变化更明显,差异有统计学意义(P<0.05)。对比两组治疗期间发生的不良反应,差异无统计学意义(P>0.05)。结论 慢阻肺6号方联合穴位贴敷治疗AECOPD患者效果显著,可有效改善患者免疫功能,安全性较好。

Objective To explore the effect of slow obstruction pulmonary 6 formula combined with acupoint application on the efficacy of acute exacerbation chronic obstructive pulmonary disease(AECOPD)and immune function.Methods Prospective analysis,80 cases of AECOPD patients admitted to the Ganzhou Hospital of Traditional Chinese Medicine from January 2022 to June 2023 were selected as the study object,and were divided into 40 cases each in the treatment group and the control group by the method of randomized numerical table.The control group was given routine symptomatic treatment,and the treatment group was combined with slow obstructive pulmonary 6 formula combined with acupoint application treatment,comparing the clinical efficacy,immune function[the percentage of T lymphocyte subpopulations CD4^(+),CD8^(+) and the change of CD4^(+)/CD8^(+)ratio]and adverse reactions of the two groups.Results The effective rate of the treatment group was higher than that of the control group,and the difference was statistically significant(P<0.05);after 10 d of treatment,the CD4^(+),CD4^(+)/CD8^(+)of both groups were higher than that before treatment,and the CD8 was lower than that before treatment,and changes in various indexes of the treatment group were more obvious,and the difference was statistically significant(P<0.05).When comparing the adverse reactions occurring in the treatment period of the two groups,the difference was not statistically significant(P>0.05).Conclusion Chronic obstructive pulmonary 6 formula combined with acupoint application treatment of AECOPD patients is effective,can effectively improve the patient's immune function,safety is better.