复方异丙托溴铵联合溴己新对煤工尘肺合并感染患者血气分析及肺功能的影响

Effect of Compound Ipratropium Bromide Combined with Bromohexine on Blood Gas Analysis and Lung Function in Coal Workers'Pneumoconiosis Patients with Concurrent Infection

目的 探讨复方异丙托溴铵联合溴己新对煤工尘肺合并感染患者血气分析及肺功能的影响。方法 选择2020年1月至2022年12月被萍乡市第三人民医院收治的80例煤工尘肺合并感染患者,按随机数字表法分为对照组(40例)和观察组(40例)。对照组用溴己新治疗,观察组用复方异丙托溴铵联合溴己新治疗,治疗10天。比较两组临床疗效、血气分析、肺功能及不良反应。结果 观察组临床疗效为95.00%,与对照组的80.00%相比,差异有统计学意义(P<0.05)。治疗后,观察组血氧饱和度(95.36±2.79)%、动脉血氧分压(83.13±4.14)mmHg,高于对照组的(92.24±2.13)%、(77.56±3.25)mmHg;动脉血二氧化碳分压(PaCO_(2))(36.85±2.11)mmHg,低于对照组的(40.56±2.65)mmHg;第一秒用力呼气容积(FEV_(1))(2.15±0.31)L、用力肺活量(FVC)(2.65±0.20)L、一秒率(FEV_(1)/FVC)指标为(81.13±7.19)%,高于对照组的(1.69±0.23)L、(2.34±0.14)L、(72.22±5.26)%;差异有统计学意义(P<0.05)。观察组不良反应为17.5%,与对照组的15.00%相比较,差异无统计学意义(P>0.05)。结论 复方异丙托溴铵联合溴己新治疗煤工尘肺合并感染患者疗效显著,可有效地改善患者血气指标及肺功能,且安全可靠。

Objective To investigate the effect of compound ipratropium bromide combined with bromohexine on blood gas analysis and lung function in coal workers'pneumoconiosis with concurrent infection.Methods 80 coal workers'pneumoconiosis with concurrent infection patients admitted to Pingxiang Third People's Hospital from January 2020 to December 2022 were randomly divided into a control group(40 cases)and an observation group(40 cases)using a random number table method.The control group was treated with bromohexine,and the observation group was treated with compound ipratropium bromide combined with bromohexine,all treated for 10 days.The clinical efficacy,blood gas analysis index,lung function and adverse effects were compared in the two groups.Results The clinical efficacy of the observation group was 95.00%,compared with 80.00%of the control group(P<0.05).After treatment,Oxygen saturation(95.36±2.79)%,arterial blood oxygen partial pressure(83.13±4.14)mmHg,were higher than the control group(92.24±2.13)%,(77.56±3.25)mmHg(P<0.05).The arterial blood partial carbon dioxide pressure index(36.85±2.11)mmHg was lower than the control group(40.56±2.65)mmHg.Forced expiratory volume(2.15±0.31)L,forced vital capacity(2.65±0.20)L,one second rate(81.13±7.19)%,were higher than the control group(1.69±0.23)L,(2.34±0.14)L,(72.22±5.26)%,were statistical difference(P<0.05).Adverse reactions in the observation group were 17.5%,compared to 15.00%of the control group,there was no statistical difference(P>0.05).Conclusion Compound ipratropium bromide combined with bromohexine is effective in the treatment of coal workers'pneumoconiosis with concurrent infection patients,and can effectively improve the blood gas index and lung function of patients,and is safe and reliable.