帕利哌酮与阿立哌唑治疗精神分裂症的临床疗效及作用机制

The clinical efficacy and mechanism of paliperidone and aripiprazole in the treatment of schizophrenia

目的探讨帕利哌酮与阿立哌唑治疗精神分裂症的临床疗效及作用机制。方法选取2019年2月至2022年2月于莆田市慈康医院就诊的80例精神分裂症患者作为研究对象,按照随机数字表法分为对照组与研究组,每组40例。对照组给予阿立哌唑片口服治疗,研究组给予帕利哌酮片口服治疗。比较两组临床疗效与个人和社会功能量表(PSP)、认知功能筛查量表(CASI)、阳性与阴性症状量表(PANSS)评分,以及不良反应发生情况。结果研究组治疗总有效率为80.00%,高于对照组的57.50%,差异有统计学意义(P<0.05)。治疗后,两组社会有益活动、个人关系和社会关系、自我照料、扰乱和攻击行为评分均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05)。治疗后,两组注意力、定向力、记忆力、思维流畅性、语言表达力评分均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05)。治疗后,两组阳性症状、阴性症状、一般精神病理评分及总分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。研究组不良反应发生率为7.50%,低于对照组的75.00%,差异有统计学意义(P<0.05)。结论帕利哌酮治疗精神分裂症疗效显著,能促进患者病情恢复进程,药物治疗效果和安全性更好,值得临床推广应用。

Objective To explore the clinical efficacy and mechanism of paliperidone and aripiprazole in the treatment of schizophrenia.Methods A total of 80 patients with schizophrenia treated in Putian Cikang Hospital from February 2019 to February 2022 were selected as the study subjects,and they were divided into the control group and the study group by random number table method,with 40 cases in each group.The control group was treated with aripiprazole tablets and the study group was treated with paliperidone tablets.The clinical efficacy,personal and social performance(PSP),cognitive function screening scale(CASI),positive and negative symptom scale(PANSS)scores,and the occurrence of adverse reactions were compared between the two groups.Results The total response rate in the study group was 80.00%,which was higher than 57.50%in the control group,and the difference was statistically significant(P<0.05).After treatment,the social beneficial activities,personal relationships and social relationships,self-care,disturbance and aggressive behavior of the two groups were higher than those before treatment,and the study group was higher than the control group,and the differences were statistically significant(P<0.05).After treatment,the attention,orientation force,memory,subtle fluency,and verbal expression scores of the two groups were higher than those before treatment,and the study group was higher than the control group,and the differences were statistically significant(P<0.05).After treatment,the sexual symptoms,negative symptoms,general psychopathology scores and total scores were lower than those before treatment,and the study group was lower than the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the study group was 7.50%,which was lower than that 75.00%in the control group,and the difference was statistically significant(P<0.05).Conclusion Paripipidone is effective in the treatment of schizophrenia,can better alleviate the symptoms of patients,improve the recovery process,and have better drug treatment effect and safety,which is worthof clinical promotion and application.