腹膜间皮细胞在腹膜转移过程中的双向作用

Bidirectional role of peritoneal mesothelial cells during peritoneal metastasis

腹膜是胃癌、结直肠癌、卵巢癌等腹盆腔肿瘤常见的转移部位,腹膜转移的发生常预示着极差的预后,因此探究腹膜转移的机制意义重大。腹膜转移的核心理论基础为“种子与土壤”学说,而腹膜间皮细胞(peritoneal mesothelial cells,PMCs)作为“土壤”中最主要的细胞成分,受到了学界越来越多的重视。过去,PMCs单层往往被视为对抗肿瘤细胞的重要防线,有新的观点提出PMCs在一定条件下具有促进腹膜转移的作用。该文综述了PMCs在不同状态下所具有的不同生物学功能,维持PMCs的屏障作用对控制腹膜转移具有重要意义。

Peritoneum is a common metastatic site of such abdominopelvic tumors as gastric cancer,colorectal cancer and ovarian cancer.The occurrence of peritoneal metastasis often hints at a poor prognosis.Thus it is imperative to elucidate the underlying mechanism of peritoneal metastasis."Seed and Soil"theory,as a core theoretical basis of peritoneal metastasis,and peritoneal mesothelial cells(PMCs),as the most important cellular component in"soil",have received growing attention from academic circles.Previously monolayer of PMCs has been treated as an important line of defense against tumor cells.New ideas have suggested that PMCs may promote peritoneal metastasis under certain conditions.This review summarized diverse biological functions of PMCs in various states.Maintaining the barrier function of PMCs is vital for managing peritoneal metastasis.