仁寿县2053例HIV/AIDS患者合并HCV、TP感染现状调查分析

Investigation and analysis of the current situation of HCV and TP Co-infection HIV/AIDS patients in Renshou County 2053

目的分析仁寿县艾滋病病毒感染者(HIV)/艾滋病病人(AIDS)合并丙型肝炎病毒(HCV)、梅毒螺旋体(TP)感染情况,为制定“多病同防”措施提供依据。方法将仁寿县2023年1至7月做HIV病毒载量检测的2053份HIV/AIDS患者血清,用酶联免疫吸附法进行HCV抗体、TP抗体检测,TP抗体阳性再进行TRUST试验复验。使用SPSS 26.0软件进行统计学分析,率的比较采用χ^(2)检验,以P<0.05为差异有统计学意义。结果2053例HIV/AIDS患者中,检出合并HCV抗体阳性29例(1.4%)、TP抗体阳性445例(21.7%)、TP抗体+TRUST双阳性241例(11.7%)、HCV抗体+TP抗体双阳性14例(0.7%)、HCV抗体+TP抗体+TRUST三阳性5例(0.3%);不同感染途径HCV抗体、TP抗体+TRUST双阳性率组间差异有统计学意义(P均<0.05),HCV抗体阳性以静脉注射毒品途径感染最高,TP抗体+TRUST双阳性异性性接触途径感染高于同性性接触;不同接触史男女非婚商业异性性接触、非婚非商业异性性接触、配偶/固定性伴3种接触史感染率组间差异有统计学意义(P均<0.05),男性非婚商业异性性接触高于女性,女性非婚非商业异性和配偶/固定性伴性接触高于男性;不同性别TP抗体阳性率、TP抗体+TRUST双阳性率组间差异有统计学意义(P均<0.05),男性均高于女性;不同年龄段HCV抗体阳性率组间差异有统计学意义(P<0.05),31~50岁年龄组阳性率高于其他组别。结论仁寿县HIV/AIDS患者存在一定程度HCV、TP合并感染,其中合并现症梅毒感染率较高,应加强HIV/AIDS患者HCV、TP等相关检测,为疾病的诊断、治疗和精准防控提供科学依据。

Objective To analyze the co-infection of Hepatitis C Virus(HCV)and Treponema pallidum(TP)among HIV/AIDS patients in Renshou County,providing a foundation for the implementation of“comprehensive disease prevention”measures.Methods Serum samples from 2053 HIV/AIDS patients who underwent HIV viral load testing in Renshou County from January to July 2023 were tested for HCV antibodies and TP antibodies using enzyme-linked immunosorbent assay,and TP antibody-positive samples were retested with the TRUST assay.SPSS 26.0 software was used for statistical analysis,andχ^(2)test was used to compare rates.P<0.05 was considered statistically significant.Results Among the 2053 HIV/AIDS patients,29 cases(1.4%)tested positive for HCV antibodies,445 cases(21.7%)tested positive for TP antibodies,241 cases(11.7%)tested positive for both TP antibodies and TRUST,14 cases(0.7%)were positive for both HCV antibodies and TP antibodies,and 5 cases(0.3%)were positive for HCV antibodies,TP antibodies,and TRUST.Statistically significant differences were observed in the HCV antibody and TP antibody plus TRUST positivity rates among different infection pathways(all P<0.05).The highest prevalence of HCV antibody positivity was observed in individuals infected through intravenous drug use,while TP antibody+TRUST positivity was higher in individuals infected through heterosexual contact compared to homosexual contact.Statistically significant differences were observed among three groups of contact histories:non-marital commercial heterosexual contact,non-marital non-commercial heterosexual contact,and marital/stable partner contact(all P<0.05).Males showed higher infection rates in non-marital commercial heterosexual contact,whereas females exhibited higher rates in non-marital non-commercial heterosexual contact and marital/stable partner contact compared to males.There were statistically significant differences in TP antibody positivity rates and TP antibody+TRUST positivity rates between different genders(all P<0.05),with males having higher rates than females.Statistically significant differences were also observed in the positive rates of HCV antibodies among different age groups(P<0.05),with the 31-50 age group showing higher rates than other age groups.Conclusions Renshou County's HIV/AIDS patients exhibit a certain degree of co-infection with HCV and TP,with a notably higher co-infection rate of syphilis.Therefore,it is essential to enhance HCV,TP,and related infection screening among the HIV/AIDS population,so as to provide a scientific basis for the diagnosis,treatment,and precise prevention and control of these diseases.