瑞巴派特联合三联疗法治疗老年消化性胃溃疡的临床效果分析

Analysis of Clinical Effect of Combined with Triple Therapy for Peptic Gastric Ulcer in Old Patients

目的探讨老年消化性胃溃疡采用瑞巴派特联合三联疗法治疗的临床效果。方法选择丹徒区人民医院2020年4月至2023年10月收治的老年消化性胃溃疡患者94例,按随机数表法分为两组,各47例。对照组采用常规三联疗法,观察组在此基础上加用瑞巴派特。对比两组临床治疗效果、症状改善时间、胃黏膜形态学与不良反应。结果较之对照组,观察组治疗总有效率更高,差异有统计学意义(P<0.05)。较之对照组,观察组恶心、嗳气、反酸及腹痛症状改善时间均更短,差异有统计学意义(P<0.05)。观察组治疗后胃黏膜厚度、腺体密度评分均较对照组低,差异有统计学意义(P<0.05)。两组不良反应总发生率对比,差异无统计学意义(P>0.05)。结论采用瑞巴派特联合三联疗法治疗老年消化性胃溃疡的效果确切、安全性高,对患者症状、胃黏膜形态的改善效果明显。

Objective:To Objective to explore the clinical effect of rebamipide combined with triple therapy in the treatment of peptic ulcer in the elderly.Methods:94 elderly patients with peptic ulcer admitted to the People's Hospital of Dantu District from April 2020 to October 2023 were randomly divided into two groups,47 cases in each group.The control group was given routine triple therapy,and the observation group was given rebamipide on the basis of this.The clinical treatment effect,symptom improvement time,gastric mucosa morphology and adverse reactions were compared between the two groups.Results:Compared with the control group,the total effective rate in the observation group was higher,and the difference was statistically significant(P<0.05).Compared with the control group,the improvement time of nausea,belching,acid regurgitation and abdominal pain in the observation group was shorter,and the difference was statistically significant(P<0.05).After treatment,the scores of gastric mucosa thickness and gland density in the observation group were lower than those in the control group,with statistical significance(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Rebapet combined with triple therapy is effective and safe in the treatment of peptic ulcer in the elderly,and has obvious effect on improving the symptoms and gastric mucosal morphology.