NLRP3炎症小体在PRRSV调控机体炎症中的作用

Role of NLRP3 Inflammasomes in Regulating Inflammation during PRRSV Infection

猪繁殖与呼吸综合征病毒(PRRSV)是一种严重危害猪类养殖业的病毒,引起了广泛关注,炎症作为机体对PRRSV感染的主要反应之一,在病毒感染过程中发挥重要作用。NOD样受体热蛋白结构域相关蛋白3(NLRP3)炎症小体作为一种重要的细胞内炎症调节机制,在PRRSV感染中扮演着不可忽视的角色。本文重点综述NLRP3炎症小体对PRRSV感染机体炎症的调控作用,并探讨其在PRRSV防控中的潜在应用价值,为PRRSV感染的机制和治疗研究提供参考。

Porcine reproductive and respiratory syndrome virus(PRRSV)is a virus that seriously threatens the swine industry,attracting widespread attention.Inflammation,as one of the main responses of the body to PRRSV infection,plays a crucial role in the process of viral infection.The NOD-like receptor thermal protein domain associated protein 3(NLRP3)inflammasome,as an important intracellular inflammatory regulatory mechanism,plays an indispensable role in PRRSV infection.This review focuses on the regulatory role of NLRP3 inflammasome in inflammation during PRRSV infection and discusses its potential application value in PRRSV prevention and control,providing reference for the mechanism and treatment research of PRRSV infection.