支链氨基酸代谢在肿瘤发生发展中的作用

The roles of branched-chain amino acids metabolism in tumorigenesis and progression

支链氨基酸(branched-chain amino acids,BCAAs),包括亮氨酸、缬氨酸和异亮氨酸,在调节体内代谢平衡、维持正常生命活动中发挥着重要作用。许多研究报道了它们在肥胖、糖尿病和心血管等疾病中的代谢和功能。近些年研究表明,BCAAs代谢在肿瘤发生发展中也起着重要作用。本文综述了BCAAs代谢在该方面的研究进展,包括与表观遗传调控的关系,特别是围绕肿瘤代谢重塑和代谢感知,讨论了其在肿瘤细胞和肿瘤微环境(tumor microenvironment,TME)中的作用。深入了解BCAAs代谢在肿瘤发生发展中的作用及其机制有助于为开发新的肿瘤治疗策略提供理论基础。

Branched-chain amino acids(BCAAs),including leucine,valine,and isoleucine,play crucial roles in regulating metabolic balance and maintaining physiological functions in the body.Extensive studies have been focused on their implications in obesity,diabetes,and cardiovascular diseases.Nevertheless,accumulating evidence suggests that BCAAs metabolism also plays significant roles in tumorigenesis and progression.In this review,we overview recent progress of the study on BCAAs metabolism including its relationship with epigenetic regulation.Particularly,we discuss the metabolic reprogramming and metabolic sensing of BCAAs and its intermediate metabolites in tumor cells and microenvironment to decipher their functions.An enhanced understanding of the roles and mechanism of BCAAs metabolism in tumorigenesis and progression will contribute to development of novel therapeutic strategies against tumor.