精神分裂症患者动态功能连接和效应连接的功能磁共振成像研究

Dynamic functional connectivity and effective connectivity of postcentral gyrus in patients with schizophrenia

目的:采用静息态功能磁共振成像方法,探究精神分裂症患者脑动态活动特征。方法:招募43例符合精神障碍诊断与统计手册第4版(DSM-IV)诊断标准的精神分裂症患者和31例正常对照,每个被试均接受静息态功能磁共振成像扫描,采用阳性与阴性症状量表评估患者症状严重程度,DPABI软件用于计算计算动态局部一致性(dReHo)和动态功能连接(dFC),采用格兰杰因果分析(GCA)计算dReHo显著脑区和全脑其他脑区之间效应连接,采用独立样本t检验比较两组被试dReHo和dFC的组间差异。结果:与正常对照组相比,精神分裂症患者左侧中央后回(P<0.01,团簇水平FWE校正)dReHo下降;患者左侧中央后回和左侧额中回、左内侧额上回、右侧锯状裂、左内侧旁扣带回、右侧补充运动区之间的dFC高于正常对照组(P<0.01);患者从左侧中央后回向右侧豆状壳核的效应连接下降(P<0.02,团簇水平FWE校正)。结论:精神分裂症患者中央后回动态功能连接和效应连接均存在异常。

Objective:To explore the characteristics of brain dynamic activity in patients with schizophrenia by using functional magnetic resonance imaging(fMRI).Methods:Forty-three patients with schizophrenia and 31 normal controls were recruited and under fMRI scanning.The Positive and Negative Symptom Scale(PANS)was used to assess the severity of clinical symptoms.The DPABI software were used to compute dReHo and dFC.Granger causality analysis was used to calculate the effective connectivity between the significant brain regions of dReHo and the whole brain.Two sample t-test was performed to compare the difference of dReHo and dFC between patients with schizophrenia and normal controls.Results:The dReHo of left postcentral gyrus(LPG)(P<0.01,cluster-level FWE corrected)in patients with schizophrenia was decreased.The Dfc was increased between left postcentral and left middle frontal gyrus,left superior medial frontal gyrus,right calcarine,left medial cingulum gyrus,right supplementary motor area(P<0.01,uncorrected).Compared with normal controls,patients with schizophrenia showed decreased effective connectivity from LPG to right putamen.Conclusion:It suggests that the abnormal functional activity of the postcentral gyrus might contribute to the neural physiopathology in patients with schizophrenia.