二甲双胍通过调节黏蛋白菌改善2型糖尿病肠道通透性的研究进展

Research progress on metformin in improving intestinal permeability in type 2 diabetes mellitus by regulating mucin bacteria

二甲双胍广泛用于治疗T2DM。肠道屏障功能紊乱引起有害物质及微生物经肠粘膜入血,导致血糖升高及IR。二甲双胍可增加肠上皮细胞通透性,调节肠道微生物菌群并降低炎性因子表达。本文综述二甲双胍通过调节黏蛋白菌改善T2DM肠道通透性的研究进展。

Metformin is widely used in the treatment of type 2 diabetes mellitus (T2DM).Dysfunction of the intestinal barrier causes harmful substances and microorganisms to enter the blood streamthrough the intestinal mucosa,leading to elevated blood glucose and insulin resistance. Metformin canincrease the permeability of intestinal epithelial cells,regulate the gut microbiota,and reduce the expression ofinflammatory factors. This article reviews the research progress of metformin in improving intestinalpermeability in T2DM by regulating mucin bacteria.