HES1在神经胶质瘤中的研究进展

Research progress of HES1 in glioma

神经胶质细胞瘤是常见的颅内原发恶性肿瘤,现有的治疗方案存在局限,高级别神经胶质瘤经手术及放化疗后无法完全治愈。HES1属于前神经元碱性螺旋-环-螺旋基因(BHLH)家族的转录因子,在细胞发育、分化和增殖中起重要作用。在胶质瘤发展和恶化过程中HES1的角色备受瞩目。本文旨在通过回顾相关研究,探究HES1在胶质瘤发展过程中的作用机制以及其对治疗方式的影响,对这一领域的进展进行综述。

Glioma is a common primary malignant intracranial tumor.Existing treatment modalities have limitations,as high-grade glioma often remains incurable even after surgical intervention and radiochemotherapy.HES1 belongs to the basic helix-loop-helix(BHLH)family of transcription factors and plays a crucial role in cell development,differentiation and proliferation.The role of HES1 in the progression and worsening of glioma has garnered significant attention.This review aims to explore the mechanistic role of HES1 in glioma development and its impact on treatment modalities by reviewing relevant studies and summarizing advancements in this field.