冠心宁片在治疗冠心病合并颈动脉粥样硬化斑块中的作用

Effect of Guanxinning Tablet in the Treatment of Coronary Heart Disease with Carotid Atherosclerotic Plaque

目的探讨冠心宁片在治疗冠心病合并颈动脉粥样硬化斑块中的作用。方法选择2020年1月~2022年1月浙江省德清县第三人民医院收治的冠心病合并颈动脉粥样硬化斑块患者98例,随机分为常规治疗组和冠心宁片组,每组49例。常规治疗组采用阿司匹林、氯吡格雷、单硝酸异山梨酯、阿托伐他汀、富马酸比索洛尔、硝酸甘油治疗,冠心宁片组在常规治疗组基础上加用冠心宁片治疗,1.52g/次,3次/d。两组均治疗3个月。比较两组治疗前后临床疗效、颈动脉超声指标(IMT、斑块面积、左右侧PWV)、心脏自主神经功能指标(LF/HF、SDNN、NO)、内皮功能(ET-1)、心功能(CO、LVEDD、LVESD、LVEF)及研究期间不良反应(胃肠道反应、皮疹、头晕头痛)发生情况。结果治疗3个月后,冠心宁片组总有效率(91.84%)较常规治疗组(75.51%)更高(P<0.05)。治疗3个月后,两组IMT、斑块面积、左右侧PWV、LF/HF、LVEDD、LVESD、血清ET-1水平较治疗前均降低(P<0.05),且冠心宁片组低于常规治疗组,两侧SDNN、CO、LVEF、血清NO水平均升高,且冠心宁片组高于常规治疗组(P<0.05);治疗期间两组各不良反应发生率比较差异均无统计学意义(P>0.05)。结论冠心宁片治疗冠心病合并颈动脉粥样硬化斑块疗效较好,可缓解患者颈动脉超声指标,改善其心脏自主神经功能及内皮功能,提高患者心功能的同时安全性良好。

Objective To investigate the effect of Guanxinning tablet in the treatment of coronary heart disease with carotid atherosclerotic plaque.Methods From January 2020 to January 2022,98 patients with coronary heart disease complicated with carotid atherosclerotic plaque were selected from the Third People's Hospital of Deqing County,Zhejiang Province.They were randomly divided into routine treatment group and Guanxinning tablet group,with 49 cases in each group.The conventional treatment group was treated with aspirin,clopidogrel,isosorbide mononitrate,atorvastatin,bisoprolol fumarate,and nitroglycerin.The Guanxinning tablet group was treated with Guanxinning tablets in addition to the conventional treatment group,1.52g/time,3 times a day.Both groups were treated for 3 months.Compare the clinical efficacy,carotid artery ultrasound indicators(IMTplaque area left and right PWV),cardiac autonomic function indicators(LF/HF、SDNN、NO),endothelial function(ET-1),cardiac function(CO,LVEDD,LVESD,LVEF),and incidence of adverse reactions(gastrointestinal reactions,rash,dizziness and headache)during the study period between two groups before and after treatment.Results After 3 months of treatment,the total effective rate of the Guanxinning tablet group(91.84%)was higher than that of the conventional treatment group(75.51%)(P<0.05).After 3 months of treatment,two groups of IMT,plaque area,left and right PWV LF/HF、LVEDD、LVESD、The serum ET-1 levels decreased compared to before treatment(P<0.05),and the Guanxinning tablet group was lower than the conventional treatment group.The SDNN、CO、LVEF and serum NO levels increased in both groups,and the Guanxinning tablet group was higher than the conventional treatment group(P<0.05);There was no statistically significant difference in the incidence of adverse reactions between the two groups during the treatment period(P>0.05).Conclusion Guanxinning Tablet is effective in the treatment of coronary heart disease with carotid atherosclerotic plaque.It can alleviate the carotid ultrasound indicators,improve the cardiac autonomic nervous function and endothelial function,and improve the cardiac function of patients with good safety.