一种药食同源组合物提高运动耐力效果研究

Effect of medicinal and edible composition on exercise endurance

运动耐力不足是限制运动员和健身爱好者运动表现的主要原因,提高运动耐力能满足运动员提高运动成绩、普通人提升身体素质、劳动者长时间体力劳动的需求,但目前尚缺乏适合日常食用安全高效的耐力类运动功能食品。元动力作为一种新型药食同源化合物的组合物具有较显著的提高运动耐力作用,但其机制尚待进一步系统研究。该研究采用药食同源组合物(阿洛糖28%、蔗糖12%、葡萄糖8%、5-羟甲基糠醛12%、棕榈酸18%、亚油酸18%、人参皂苷3%、姜酚1%),通过负重力竭游泳实验测定运动耐力,采用红外热成像法监测小鼠整体能量代谢,通过HE染色法观测肌肉组织形态,采用脲酶法、乳酸脱氢酶法及蒽酮-硫酸法测定血尿素氮、血乳酸、肝糖原及肌糖原含量,采用GC-MS法测定短链脂肪酸含量,研究结果如下:(1)低、高剂量元动力干预后小鼠负重力竭游泳时间较空白组分别延长119.8%、257.4%(P<0.05);(2)低、高剂量元动力干预后,整体能量代谢显著提高,肌肉细胞变形和破裂减轻,肌糖原含量增加,血尿素氮、血乳酸含量降低,粪便中丁酸含量增加。综上所述,元动力能够显著提高机体能量代谢,增加丁酸生成,降低有害代谢产物,增加肌糖原储备,提高运动耐力。

The primary factor limiting athletic performance for athletes and fitness enthusiasts was inadequate exercise endurance.Enhancing exercise endurance not only helps athletes perform better on the field but also helps the general public become more physically healthy.But yet endurance sports functional foods that are safe and efficient for daily consumption are currently unavailable.Yuandongli(YDL),a medicinal and edible compound,has a significant effect on improving exercise endurance,but its mechanism has yet to be further studied systematically.The composition used in this study composed of 28%of allulose,12%of sucrose,8%of glucose,12%of 5-hydroxymethylfurfural,18%of palmitic acid,18%of linoleic acid,3%of ginsenoside,and 1%of gingerol.In this study,mice were administered YDL by gavage.Exercise endurance was determined by a weight-exhaustion swimming test.Blood urea nitrogen(BUN),blood lactate(BLA),liver glycogen(LG),and muscle glycogen(MG)were determined by biochemical methods.Short-chain fatty acids(SCFAs)were determined by GC-MS.The metabolism of mice was monitored by infrared thermography.Morphology of muscle tissue was observed by HE staining.The changes in physiological and biochemical indexes in each group were compared,and the results were that after low and high doses of YDL intervention,the weight-exhaustion swimming time of mice was 119.8%and 257.4%(P<0.05)longer than the blank group,respectively.After low and high-dose YDL intervention,the energy metabolism significantly improved,muscle tissue deformation and rupture reduced,MG content increased,BUN and BLA content decreased,and fecal butyric acid content increased.In summary,YDL can significantly improve energy metabolism,increase butyric acid production,reduce harmful metabolites,increase MG reserves,and improve exercise endurance.