基于CiteSpace的柴胡桂枝汤相关研究可视化分析

Visualized analysis of related researches on Chaihu Guizhi Decoction based on CiteSpace

目的:运用CiteSpace 6.4.2软件对柴胡桂枝汤进行文献数据可视化分析,研究柴胡桂枝汤的发展趋势和聚焦热点。方法:检索中国知网(CNKI)中柴胡桂枝汤相关研究的文献,检索时间从2013年1月1日—2023年6月30日,导出格式为Refworks,数据录入CiteSpace 6.4.2软件,生成发文作者、研究机构和关键词的知识图谱。结果:共纳入490篇相关文献,298位作者,其中王庆国发表文章数量最多,为14篇。按照机构发文量排名,北京中医药大学(19篇)为发文机构首位,其次为山东中医药大学(11篇)、天津中医药大学(10篇)。共涉及227个关键词,频次排名前3位的是经方(48次)、名医经验(30次)、伤寒论(18次);关键词聚类分析,共得出9个聚类,分别是经方、名医经验、小柴胡汤、伤寒论、综述、冠心病、失眠、头痛、医案。结论:柴胡桂枝汤的临床应用仍是当下研究的热点问题。柴胡桂枝汤不仅可以治疗情志不舒、外感发热,在治疗心绞痛、脾胃疾病、内分泌系统疾病方面也有较好的疗效;同时,基于药理代谢研究发现柴胡桂枝汤具有抗肿瘤、调节免疫的功能。各大研究团队之间联系不紧密,未形成广泛合作网络。

Objective:To visualize the literature data of Chaihu Guizhi Decoction by using CiteSpace 6.4.2 software,and to study the development trend and focus of Chaihu Guizhi Decoction.Methods:The literature related to Chaihu Guizhi Decoction in CNKI database was searched from January 1,2013 to June 30,2023.The format was exported as Refworks,and the data were entered into CiteSpace 6.4.2 software to generate the mapping knowledge domain of authors,research institutions and keywords.Results:A total of 490 relevant articles and 298 authors were included,of which Wang Qingguo published the largest number of articles(14).In terms of the number of publications,Beijing University of Chinese Medicine(19 articles)ranked first,followed by Shandong University of Chinese Medicine(11articles)and Tianjin University of Chinese Medicine(10 articles).A total of 227 keywords were involved,and the top three were classical prescription(48 times),famous doctors′experience(30 times),and Treatise on Febrile Diseases(18times).Keyword cluster analysis showed that a total of 9 clusters were obtained,namely classical prescription,famous doctors′experience,Xiaochuhu Decoction,Treatise on Febrile Diseases,review,coronary heart disease,insomnia,headache and medical records.Conclu⁃sion:The clinical application of Chaihu Guizhi Decoction is still a hot topic of current research.Chaihu Guizhi Decoction can not only treat emotional depression and exogenous fever,but also have good curative effect on angina pectoris,spleen and stomach system diseases and endocrine system diseases;at the same time,based on pharmacological metabolism researches,Chaihu Guizhi Decoction has been found to have anti-tumor and immune-regulating functions.However,the research teams are not closely connected and do not form an extensive cooperation network.