中医药通过调控细胞自噬改善糖尿病心肌病的研究现状

Research status of Chinese medicine in improving diabetic cardiomyopathy by regulating cellular autophagy

糖尿病心肌病(DCM)的发病机制复杂。自噬作为细胞重要的维稳机制,其水平是否稳定与DCM病程的发展密切相关。众多中药及复方的有效成分都可以通过降血糖、抗凋亡、抗炎、抗氧化应激等机制来调控自噬水平,减轻自噬导致的心肌损伤,改善心功能,延缓DCM的发生发展。本文就近5年的研究成果展开梳理,以期为防治DCM的中医药的研发与临床应用提供思路和参考。

The pathogenesis of diabetic cardiomyopathy(DCM)is complex.Autophagy plays a pivotal role in the development of DCM,and whether its level is stable or not is closely related to the development of the course of DCM.Numerous active components found in traditional Chinese medicines and compound formulations have demonstrated the ability to modulate autophagy levels.These interventions occur through various mechanisms,such as hypoglycemic,anti-apoptotic,anti-inflammatory,and anti-oxidative stress pathways.By mitigating autophagy-induced myocardial damage,enhancing cardiac function,and slowing the progression of DCM,these compounds offer promising avenues for DCM management.This paper aims to consolidate and present research findings from the last 5 years.Our goal is to provide valuable insights and references for the research,development,and clinical application of Chinese medicine in the context of combating DCM.