低温手足套联合“五防”教育在预防紫杉类药物相关周围神经病变中的应用

The application of low-temperature hand and foot covers combined with"five precautions"education in the prevention of taxane-related peripheral neuropathy

目的探讨非药物干预在预防紫杉类药物相关周围神经病变中的应用效果。方法选取蚌埠医科大学第一附属医院肿瘤内科住院且接受紫杉类药物化疗的252例患者作为研究对象,将2022年7—12月的125例患者作为对照组,2023年1—6月的127例患者作为观察组。对照组采用肿瘤内科化疗护理常规,观察组采用低温手足套联合“五防”教育。比较2组患者周围神经病变的症状体验、患者日常生活质量和居家安全不良事件情况。结果观察组手指/手麻木、脚趾/脚麻木、脚趾/脚刺痛、手指/手或脚趾/脚不舒服、肌肉或关节痛的发生率、症状严重程度及症状困扰程度均低于对照组(P<0.05);观察组影响握持小物品[38.58%(49/127)]、睡眠[46.46%(59/127)]、写字[55.91%(71/127)]、做平时的家务[62.99%(80/127)]的率均低于对照组[52.00%(65/125)、61.60%(77/125)、69.60%(87/125)、82.40%(103/125),P<0.05];观察组居家跌倒[5.51%(7/127)]和磕碰[7.87%(10/127)]发生率低于对照组[16.00%(20/125)和18.40%(23/125),P<0.05]。结论采用低温手足套联合“五防”教育可有效减少紫杉类药物相关周围神经病变发生,改善患者症状体验和日常生活质量,防止居家安全不良事件的发生。

Objective To explore the application effect of non-pharmacological intervention in the prevention of taxane-related peripheral neuropathy.Methods A total of 252 patients who were hospitalized in the Department of Oncology of the First Affiliated Hospital of Bengbu Medical University and received taxane-based chemotherapy were selected as the study subjects.Among them,125 patients from July to December 2022 were taken as the control group,and 127 patients from January to June 2023 were taken as the observation group.Patients in the control group received routine chemotherapy care from the medical oncology department,while patients in the observation group received low-temperature hand and foot covers combined with"five precautions"education.The peripheral neuropathy including symptom experience,quality of daily life,and adverse home safety events between the two groups were compared.Results The incidence,severity,and degree of symptom distress of finger/hand numbness,toe/foot numbness,toe/foot tingling,finger/hand or toe/foot discomfort,and muscle or joint pain in the observation group were lower than those in the control group(P<0.05).The observation group had lower rates of holding small items[38.58%(49/127)],sleeping[46.46%(59/127)],writing[55.91%(71/127)],and doing household chores[62.99%(80/127)]compared to the control group[52.00%(65/125),61.60%(77/125),69.60%(87/125),82.40%(103/125),P<0.05].The incidence of home falls(5.51%,7/127)and collisions(7.87%,10/127)in the observation group were lower than those in the control group[16.00%(20/125)and 18.40%(23/125),P<0.05].Conclusion The use of low-temperature hand and foot covers in combination with"five precautions"education can effectively reduce the occurrence of taxane-related peripheral neuropathy,improve patients'symptom experience and quality of daily life,and reduce the occurrence of adverse home safety events.