医院感染患者临床分离肠杆菌种类分布及耐药性分析

Distribution and drug resistance analysis of clinical isolates of Enterobacter

目的了解医院感染患者临床分离的肠杆菌种类分布及耐药性。方法采用细菌学检验和药敏试验方法,对某医院的医院感染患者病原学标本进行检测与分析。结果共检出肠杆菌971株,主要分离自痰液和尿液标本。在971株肠杆菌中,阴沟肠杆菌和产气肠杆菌分别占55.72%和41.10%。阴沟肠杆菌和产气肠杆菌对头孢唑啉、氨苄西林、氨苄西林/舒巴坦和头孢替坦耐药率为100%。肠杆菌对碳青霉烯类、三代头孢类、氨基糖甙类和哇诺酮类抗菌药物均比较敏感。结论某医院的医院感染患者临床分离肠杆菌以阴沟杆菌和产气肠杆菌为主,对头孢唑林等部分抗菌药物耐药严重,对碳青霉烯类和三代头孢比较敏感。

Objective To investigate the clinical distribution and drug resistance of Enterobacter in nosocomial infection.Methods Bacteriological examination and antimicrobial susceptibility test were used to detect and analyze the pathogenic specimens of nosocomial infection patients in a hospital.Results A total of 971 strains of Enterobacter were detected,mainly isolated from sputum and urine samples.Among the 971 strains of Enterobacter,Enterobacter cloacae and Enterobacter aerogenes accounted for 55.72%and 41.10%,respectively.Enterobacter cloacae and Enterobacter aerogenes were 100%resistant to cefazolin,ampicillin,ampicillin/sulbactam,and cefotetan.Enterobacteriaceae were sensitive to carbapenems,third-generation cephalosporins,aminoglycosides,and vanolone antimicrobials.Conclusion The clinical isolates of Enterobacteriaceae in patients with nosocomial infection in a hospital are mainly Cloacillus and Enterobacter aerogenes,which are seriously resistant to some antimicrobial drugs such as cefazolin,and are sensitive to carbapenems and third-generation cephalosporins.