补阳还五汤联合生肌玉红膏治疗糖尿病足的疗效

Curative Effect of Buyang Huanwu Decoction combined with Shengji Yuhong Ointment on Diabetic Foot

目的探讨补阳还五汤联合生肌玉红膏对糖尿病足溃疡(DFU)患者创面血管新生及氧化应激指标的影响。方法选取2020年1月至2022年2月河西学院附属张掖人民医院中西医结合科收治的56例DFU患者作为研究对象,随机分为观察组和对照组,各28例。对照组给予基础治疗+生肌玉红膏外涂,观察组在对照组基础上内服补阳还五汤治疗。比较两组临床疗效、创面愈合时间、创面愈合率、创面视觉模拟评分法(VAS)评分、血管新生指标[血管内皮生长因子(VEGF)、内皮抑素(ES)、血管生成素-2(Ang-2)]、氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)、晚期蛋白氧化产物(AOPP)]以及不良反应发生率。结果观察组治疗有效率高于对照组,差异有统计学意义(P<0.05);观察组治疗后创面愈合率高于对照组,且创面愈合时间短于对照组,差异有统计学意义(P<0.05);观察组治疗后VAS评分低于对照组,差异有统计学意义(P<0.05);治疗后观察组VEGF水平高于对照组,ES、Ang-2水平低于对照组,差异有统计学意义(P<0.05);治疗后观察组MDA、AOPP水平低于对照组,SOD水平高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论补阳还五汤联合生肌玉红膏可减轻DFU患者足溃疡创面疼痛感,提高临床疗效,促进创面恢复,减少截肢,且具有较高安全性。

Objective To explore the effects of Buyang Huanwu decoction combined with Shengji Yuhong ointment on wound angiogenesis and oxidative stress indexes of diabetic foot ulcer(DFU)patients.Methods Fifty-six DFU patients admitted to the Department of Integrative Chinese and Western Medicine in Zhangye People's Hospital Affiliated to Hexi University from January 2020 to February 2022 were selected as the study objects and randomly divided into the observation group and the control group,with 28 cases in each group.The control group was treated with basic treatment+Shengji Yuhong ointment,and the observation group was treated with Buyang Huanwu decoction on the basis of control group.The clinical efficacy,wound healing time,wound healing rate,wound visual analogue score(VAS),angiogenesis indexes[vascular endothelial growth factor(VEGF),endostatin(ES),angiogenin-2(Ang-2)],oxidative stress indexes[superoxide dismutase(SOD),malondialdehyde(MDA),advanced oxidation protein products(AOPP))and the incidence of adverse reactions were compared between the two groups.Results The effective rate of treatment in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).After treatment,the wound healing rate of observation group was higher than that of control group,and the wound healing time was shorter than that of control group,the difference was statistically significant(P<0.05).VAS score of observation group was lower than control group after treatment,and the difference was statistically significant(P<0.05).After treatment,the level of VEGF in observation group was higher than that in control group,and the levels of ES and Ang-2 were lower than that in control group,with statistical significance(P<0.05).After treatment,the level of MDA and AOPP in observation group was lower than that in control group,and the level of SOD was higher than that in control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Buyang Huanwu decoction combined with Shengji Yuhong ointment can alleviate the pain of foot ulcer wound in DFU patients,improve clinical efficacy,promote wound recovery,reduce amputation,and have high safety.