儿童慢性乙型肝炎抗病毒治疗的临床研究新进展

New progress on the clinical study of antiviral therapy for chronic hepatitis B in children

儿童HBV感染的诊治是乙型肝炎领域的关注热点,该文就近年来儿童慢性乙型肝炎的抗病毒治疗现状与进展进行综述,围绕HBeAg阳性慢性乙型肝炎(又称免疫清除期)儿童抗病毒治疗方案选择、HBeAg阳性HBV感染(又称免疫耐受期)儿童抗病毒治疗的必要性和婴儿HBV感染者的抗病毒治疗时机等临床问题,探讨可能影响儿童慢性乙型肝炎临床治愈的相关因素;同时依据我国专家刚刚发表的《儿童慢性乙型肝炎防治专家共识》,提出了相关的诊疗方案,以期为儿童慢性乙型肝炎的抗病毒治疗决策提供科学依据。

Diagnosis and treatment of hepatitis B virus(HBV)infection in children is a hotspot of concern in the field of HBV infection.This article reviews the current status and progress of antiviral treatment for children with chronic hepatitis B(CHB)in recent years,focusing on clinical issues such as the choice of antiviral treatment regimen for children with HBeAg-positive CHB(immune-clearance phase),the necessity of antiviral treatment for children with HBeAg-positive HBV infection(immune-tolerance phase),and the timing of antiviral treatment for infants with HBV infection,to explore the relevant factors that may affect the clinical cure of children with CHB.At the same time,based on the expert consensus on the prevention and treatment of children with CHB just published by Chinese experts,relevant diagnosis and treatment plans are proposed,with a view to providing reference and basis for clinical decision-making in children with CHB.