5-HT受体在瘙痒中的作用研究进展

The role of serotonin receptors in itch

由组胺介导的经典瘙痒信号通路以及非组胺介导的其他瘙痒信号通路对于瘙痒的产生和感知具有重要作用。5-羟色胺(5-hydroxytrptamine,5-HT)又称血清素,是一种神经递质和血管活性胺类物质,可以引起明显的瘙痒行为。大量研究揭示了5-HT及其多种受体在急性和慢性瘙痒发生中的重要性,然而介导5-HT能瘙痒的信号机制尚不完全清楚。本文对5-HT及其受体家族在瘙痒中的作用及其相关信号机制进行简要梳理总结,为瘙痒相关疾病的临床诊疗或药物开发提供一定的参考。

The classical itch signal pathway mediated by histamine and the other non-histamine mediated itch signal pathways are vital in itch generation and sensation.5-hydroxytrptamine(5-HT)or serotonin is a kind of neurotransmitter and a vasoactive amine,causing distinct itch behaviors.Accumulated studies showed that 5-HT and its receptors may play an important role in both acute and chronic itch,while the underlying mechanisms remain not fully clear.Here,we give the brief summary about the function of 5-HT and its receptor family in itch,as well as their related signaling mechanisms,hoping to offer some references for the clinical therapy or drug development of itch-associated diseases.