2-苯乙醇合成研究进展

Advances in synthesis of 2-phenylethanol

2-苯乙醇(2-phenylethanol,2-PE)是一种具有玫瑰花香的芳香族醇,是全球用量第二大的香料物质,被广泛应用于化妆品、食品和医药等行业。本文介绍了2-苯乙醇的化学合成方法及其在植物和微生物中的合成路径,总结了提高微生物合成2-苯乙醇的策略,综述了微生物从头合成2-苯乙醇的研究进展,并对2-苯乙醇合成研究前景进行展望,以期为工业化生产2-苯乙醇提供一定理论基础。

2-phenylethanol(2-PE),an aromatic alcohol with a rose fragrance,is the second most widely used flavoring substance in the world.It is widely used in the cosmetic,food,and pharmaceutical industries.This paper introduces the chemical synthesis methods of 2-PE and the synthetic pathways in plants and microorganisms,summarizes the strategies to improve the microbial synthesis of 2-PE,reviews the research progress in de novo synthesis of 2-PE in microorganisms,and makes an outlook on the research prospects,aiming to provide a theoretical basis for the industrial production of 2-PE.