3D打印水凝胶支架在宫腔粘连防治中的应用

Application of 3D Printed Hydrogel Stents in Prevention and Treatment of Intrauterine Adhesion

宫腔粘连(intrauterine adhesion,IUA)常易引发停经、不孕和复发性流产等问题,严重影响女性身心健康。临床上,对IUA的治疗主要采用手术分离方式,术后易复发,治疗效果欠佳。3D生物打印支架成为治疗IUA的前沿领域,可分隔受损区域防止粘连形成,体内可控降解无需手术取出。该支架可用于药物负载、干细胞移植及外泌体的递送,可将药物或生长因子释放到损伤区域,促进组织修复与再生。将负载干细胞或干细胞外泌体的3D打印水凝胶移植到损伤区域,可有效促进IUA的修复并改善妊娠率。3D生物打印可为患者提供个体化治疗方案,联合干细胞或干细胞外泌体的治疗策略有望成为治疗IUA的有力工具。

Intrauterine adhesion(IUA)often leads to amenorrhea,infertility,and recurrent miscarriage,seriously affecting the physical and mental health of women.Clinically,surgical separation is the main treatment for IUA,but this approach frequently results in postoperative recurrence and has poor treatment efficacy.3D bioprinted scaffolds have emerged as a cutting-edge approach in the treatment of IUA,capable of separating damaged areas to prevent adhesion formation and undergoing controllable in vivo degradation without the need for surgical removal.These scaffolds can be used for drug loading,stem cell transplantation,and exosome delivery,enabling the release of drugs or growth factors to the injured area to promote tissue repair and regeneration.Transplanting 3D bioprinted hydrogels loaded with stem cells or stem cell-derived exosomes to the damaged area can effectively promote the repair of IUA and improve pregnancy rates.3D bioprinting can provide personalized treatment plans for patients,and the combined treatment strategy with stem cells or stem cell-derived exosomes holds promise as a powerful tool for treating IUA.