肝硬化肌少症的发病机制研究进展

Advances in the pathogenesis of myasthenia gravis in liver cirrhosis

肌少症是肝硬化易被忽视的重要并发症之一,与肝硬化患者的死亡率增加和临床结局不佳有关。肝硬化肌少症的发生由多种机制共同参与,如各种分子靶点、信号通路、营养不良、代谢异常、蛋白稳态失衡、激素水平异常等。本文从肝硬化肌少症已知和可能的分子机制及原因进行综述,加深人们对肝硬化肌少症的认识与理解,为肝硬化肌少症的预防与治疗提供思路。

Sarcopeniais is one of the important complications of cirrhosis easily overlooked.It is associated with increased mortality and poor clinical outcomes in cirrhotic patients.Multiple mechanisms are involved in the development of cirrhotic sarcopenia,such as various molecular targets,signaling channels,malnutrition,metabolic abnormalities,imbalance in protein homeostasis,abnormal hormone levels,etc.This article reviews the known and possible molecular mechanisms and causes of cirrhotic sarcopenia to deepen the knowledge and understanding of cirrhotic sarcopenia,aiming to provide some ideas for the prevention and treatment of cirrhotic sarcopenia.