脓毒症诱发凝血功能障碍的研究进展

Research progress of sepsis induced coagulation

脓毒症是一种危及生命的疾病,常常诱发凝血功能障碍,甚至导致弥散性血管内凝血(Diffuse intravascularcoagulation,DIC),使病死率明显增加。脓毒症诱发凝血功能障碍(Sepsisinducedcoagulopathy,SIC)发病机制复杂,目前尚未完全阐明,主要涉及凝血系统激活、抗凝系统受损以及纤溶系统受抑3个方面,且其临床表现隐匿,临床医师很难早期识别。因此,如何及早发现并治疗SIC、延缓疾病发展进程既是目前临床诊疗的难点,也是科学研究的热点。本文就近年来SIC的发病机制、监测方法及治疗等相关研究进展进行综述。

Sepsis is a life-threatening disease that often triggers coagulation dysfunction and even leads to disseminated intravascular coagulation(DIC),significantly increasing the mortality rate.The pathogenesis of sepsis induced coagulopathy(SIC)is complex and has not been fully elucidated.It mainly involves activation of the coagulation system,damage to the anticoagulant system,and inhibition of the fibrinolytic system.Its clinical manifestations are hidden,making it difficult for clinical physicians to identify early.Therefore,how to detect and treat SIC early and delay the progression of the disease is not only a difficult point in clinical diagnosis and treatment,but also a hot topic in scientific research.This article reviews the relevant research progress of the pathogenesis,monitoring methods,and treatment of SIC in recent years.