谷胱甘肽片联合注射用腺苷蛋氨酸对于妊娠期肝内胆汁淤积症的治疗效果研究

Effect of glutathione tablet combined with adenosylmethionine for injection in the treatment of intrahepatic cholestasis of pregnancy

目的:探讨谷胱甘肽(Glutathione,GSH)片联合注射用腺苷蛋氨酸(Adenosine methionine,AME)治疗妊娠期肝内胆汁淤积症(Intrahepatic cholestasis of pregnancy,ICP)的临床效果。方法:选取2020年2月至2022年2月期间本院收治的124例ICP患者作为研究对象。随机将患者分为对照组和研究组,每组各62例。对照组采用注射用AME治疗,研究组在对照组基础上联合口服GSH片治疗。于治疗前、治疗12 d结束时,测定肝功能指标水平,观察统计两组症状消失时间、不良反应发生情况,并随访统计两组患者不良妊娠结局。结果:治疗12 d后,研究组各项肝功能指标均比对照组显著降低(P<0.05)。研究组的皮肤瘙痒、黄疸症状消失时间均比对照组显著缩短(P<0.05)。两组的不良反应总发生率无显著差异。研究组阴道分娩率明显高于对照组,剖宫产率和胎儿窘迫发生率均明显低于对照组(P<0.05);两组的流产发生率无显著差异。结论:GSH片联合注射用AME治疗ICP,能促进患者的症状消失,改善肝功能,减少不良反应及不良妊娠结局。

Objective:To investigate the clinical effect of Glutathione(Glutathione,GSH)tablets combined with Adenosine methionine(AME)in the treatment of intrahepatic cholestasis of pregnancy(ICP).Methods:124 ICP patients admitted to our hospital from February 2020 to February 2022 were selected as the study objects.The patients were randomly divided into control group and study group,62 cases in each group.The control group was treated with AME for injection;patients in the study group were administered with GSH Tablets on the basis of the control group.Before treatment and at the end of 12 days of treatment,the levels of liver function indexes were measured.The disappearance time of symptoms and the occurrence of adverse reactions in the two groups were observed and counted,and the adverse pregnancy outcomes of the two groups were statistically analyzed.Results:After 12 days of treatment,the liver function indexes in the study group were significantly lower than those in the control group(P<0.05).The disappearance time of skin pruritus and jaundice in the study group was significantly shorter than that in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups.The vaginal delivery rate of the study group was significantly higher than that of the control group,the cesarean section rate and the incidence of fetal distress were significantly lower than that of the control group(P<0.05).There was no significant difference in the incidence of abortion between the two groups.Conclusion:GSH tablets combined with AME for injection in the treatment of ICP can promote the disappearance of symptoms,improve liver function,reduce adverse reactions and adverse pregnancy outcomes.