抑郁症的发病机制及治疗药物研究进展

Research on medication and pathogenesis of depression disorder

抑郁症(depressive disorder)作为全球性主要的精神障碍,近年来其发生率呈上升趋势,已严重危害人类的身心健康,甚至可能致命。我国每年的自杀人群中40%患有抑郁症,抑郁症或成为企图自杀的主要原因。有关抑郁症的研究在近年来取得较大进展。抑郁症是多方面、多因素综合作用的结果,致病因素复杂,治愈率低,现多采用药物治疗、社会心理治疗等综合治疗,从而提高疗效。该文综述抑郁症的发病机制及目前用药现状,旨在提高对抑郁症的认识与重视,加强对抑郁症的预防治疗,并对各种抗抑郁药物的进展作综述。

Depression disorder is a major mental disease in the world.In recent years,the incidence of depression disorder is on the rise,it has seriously harmed human physical and mental health,and may even be fatal.Among the suicide population every year in China,40% suffer from depression disorder,which may be the main cause of attempted suicide.Research on depression disorder has made significant progress in recent years.Depression disorder is the result of the comprehensive effects of multiple factors,with complex pathogenic factors and low cure rates.Currently,comprehensive treatments such as medication and social psychological therapy are commonly used to improve the curative efficacy.This article reviewed the pathogenesis of depression disorder and current medication status,aimed to increase awareness and attention to depression disorder,strengthen prevention and treatment of depression disorder,and review the progress of various antidepressant drugs.