基于线粒体损伤的化疗诱导外周神经毒性机制的研究进展

Advances in the mechanism of chemotherapy-induced peripheral neurotoxicity based on mitochondrial damage

化疗药物是临床治疗恶性肿瘤的常见方法之一。但化疗诱导外周神经毒性(chemotherapy induced peripheral neurotoxicity,CIPN)已成为影响患者日常生活和工作的主要因素。线粒体损伤是导致CIPN发生、发展的一个主要原因。当线粒体损伤时,线粒体损伤相关分子模式(mitochondrial-derived damage-associated molecular patterns,mtDAMPs)被释放到细胞外环境,诱发炎症反应。因此,探讨mtDAMPs在CIPN中的作用机制具有重要意义。然而,虽有大量数据描述mtDAMPs引起CIPN的广泛影响,但确切机制尚未阐明。故该文综述mtDAMPs引起CIPN的机制及潜在治疗药物,为临床和非临床研究提供参考。

Chemotherapeutic drugs are one of the common methods for clinical treatment of tumor diseases.However,chemotherapy-induced peripheral neurotoxicity(CIPN)has become a major factor affecting patients'daily life and work.Mitochondrial damage is one of the main causes of the formation and development of CIPN.When mitochondria are damaged,mitochondrial-derived damage-associated molecular patterns(mtDAMPs)are released into the extracellular environment,which can induce inflammatory responses.Therefore,it is of great significance to explore the mechanism of mtDAMPs in CIPN.However,although there is a large amount of data describing the widespread effects of mtDAMPs on CIPN,the exact mechanism remains unelucidated.Therefore,the mechanism of mtDAMPs induced CIPN and its potential therapeutic agents were reviewed in this paper to provide reference for clinical and non-clinical studies.