脊髓损伤“气滞血瘀”病机理论与铁死亡的关系

Relationship of the Pathogenesis Theory of Qi Stagnation and Blood Stasis with Ferroptosis in Spinal Cord Injury

“气滞血瘀”是脊髓损伤重要的中医病机理论,其科学内涵有待进一步阐释。铁死亡作为脊髓损伤重要的病理,其分子生物学和病理学或许与“气滞血瘀”病机理论有密切相关性。从铁死亡的调控机制入手,揭示活血化瘀中药治疗脊髓损伤的分子机制,为中医药治疗脊髓损伤提供分子生物学依据,丰富中医药现代化的研究思路和手段。

Qi stagnation and blood stasis is a major TCM pathogenesis theory of spinal cord injury,and its scientific connotation remains to be explained.Ferroptosis is a key pathological mechanism of spinal cord injury,and its molecular biological basis and pathological process may be closely related to the pathogenesis theory of qi stagnation and blood stasis.Considering the regulatory mechanism of ferroptosis,this paper introduces the molecular mechanism of blood-activating and stasis-resolving Chinese medicines in treating spinal cord injury,aiming to provide molecular evidence for the TCM treatment of spinal cord injury and enrich the research ideas and means for the modernization of TCM.