基于组分中药理论的薏苡仁-知母药对治疗糖尿病患者的配伍特点

Compatibility Characteristics of Coicis Semen-Anemarrhenae Rhizoma Drug Pair in the Treatment of Diabetes in Patients Based on the Theory of Chinese Medicine Components

药对是源于中医传统经方或验方,依据中药配伍原则,能长期应用并指导临床实践的两味药物相对固定的配伍形式,具有协同增效或配伍减毒的作用。薏苡仁-知母为典型的清热滋阴药对,二者相辅相成,治疗阴虚热盛型糖尿病患者效果显著。其成分知母皂苷、知母多糖、芒果苷、薏苡仁多糖等对糖尿病均有较好的干预作用。现从中医理论及现代药理学研究等层面探究薏苡仁-知母药对治疗糖尿病的配伍特点,剖析主要活性成分的降糖作用和作用机制,为治疗糖尿病的新药研究提供理论基础。

Drug pair,originating from traditional Chinese medicine(TCM) classical formulas or empirical prescriptions,refers to a relatively fixed combination of two herbal drugs based on the principles of Chinese medicine compatibility.These combinations can be consistently applied and guide clinical practice,often enhancing efficacy or reducing toxicity through synergistic effects.Coicis Semen-Anemarrhenae Rhizoma is a typical drug pair known for its heat-clearing and yin-nourishing properties.They complement each other and have shown significant effectiveness in treating diabetes characterized by yin deficiency and exuberant heat.The active components,such as timosaponin,Anemarrhena asphodeloides polysaccharides,mangiferin,and coixanfrom,have demonstrated beneficial effects on diabetes.This paper explored the compatibility characteristics of Coicis Semen-Anemarrhenae Rhizoma drug pair in treating diabetes from both TCM theory and modern pharmacological research and analyzed the hypoglycemic effects and mechanisms of action of the main active components,providing a theoretical foundation for the new drug development for diabetes.