血清IL-17、INF-γ水平与肝细胞癌患者PD-1单抗治疗效果的关系

Serum IL-17 and INF-γthe Relationship Between the Level and the Therapeutic Effect of PD-1 Monoclonal Antibody in Patients with Hepatocellular Carcinoma

目的探究血清IL-17、INF-γ水平与肝细胞癌患者PD-1单抗治疗效果的关系。方法选取2023年1月至2023年8月收治的60例肝细胞癌患者作为研究对象,均接受PD-1单抗治疗。比较观察治疗有效患者与无效患者IL-17、INF-γ水平情况,IL-17、INF-γ水平与肝癌细胞患者各临床特征的关系,ROC曲线分析IL-17、INF-γ表达水平对肝癌细胞患者PD-1单抗治疗效果的预测价值关系。结果治疗有效组患者IL-17水平(14.17±2.08)pg/ml低于治疗无效组的(21.28±3.69)pg/ml,INF-γ(37.45±4.52)pg/ml高于对照组的(22.36±3.27)pg/ml(P<0.05)。在临床分期、肝外转移、血管侵犯等方面,分期越高、有肝外转移、有血管侵犯患者的IL-17水平高于分期越低、无肝转移、无血管侵犯患者(P<0.05)。分期越高、有肝外转移、有血管侵犯患者的INF-γ水平低于分期越低、无肝外转移、无血管侵犯患者(P<0.05)。通过ROC曲线的绘制可以得出:(1)IL-17、INF-γ的曲线下面积分别是0.753、0.764,均具有良好的诊断效能,但与2项联合相比,2项联合的曲线下面积0.877均高于各单一指标的曲线下面积(P<0.05);(2)IL-17、INF-γ的cut-off值是6.21 pg/ml、36.52 pg/ml;(3)2项联合的灵敏度(0.935)、特异度(0.952)均明显高于IL-17的(0.552、0.801)和INF-γ的(0.457、0.824)(P<0.05)。结论血清IL-17、INF-γ水平可对细胞癌患者PD-1单抗治疗效果进行预测评估,且两者联合预测的效能更高,具有显著的临床应用价值。

Objective Exploring serum IL-17 and INF-γThe relationship between the level and the therapeutic effect of PD-1 monoclonal antibody in patients with hepatocellular carcinoma.Methods Sixty hepatocellular carcinoma patients admitted from January 2023 to August 2023 were selected as the study subjects,all of whom received PD-1 monoclonal antibody treatment.Comparative observation of IL-17 and INF between patients with effective and ineffective treatment-γHorizontal situation,IL-17,INF-γThe relationship between levels and clinical characteristics of liver cancer cell patients,ROC curve analysis of IL-17 and INF-γThe predictive value of expression level on the therapeutic effect of PD-1 monoclonal antibody in patients with liver cancer cells.Results The IL-17 levels in the effective treatment group(14.17±2.08)pg/ml were lower than those in the ineffective treatment group(21.28±3.69)pg/ml,INF-γ(37.45±4.52)pg/ml was higher than the ineffective treatment group's(22.36±3.27)pg/ml(P<0.05).In terms of clinical staging,extrahepatic metastasis,and vascular invasion,patients with higher staging,extrahepatic metastasis,and vascular invasion had higher IL-17 levels than those with lower staging,no liver metastasis,and no vascular invasion(P<0.05).INF in patients with higher staging,extrahepatic metastasis,and vascular invasion-γThe level was lower than that of patients with lower stage,no liver metastasis,and no vascular invasion(P<0.05).By drawing the ROC curve,it can be concluded that:①IL-17,INF-γThe area under the curve of the two combinations is 0.753 and 0.764,respectively,both of which have good diagnostic performance.However,compared with the two combinations,the area under the curve of the two combinations is 0.877,which is higher than the area under the curve of each single indicator(P<0.05);IL-17,INF-γThe cut-off values are 6.21 pg/ml and 36.52 pg/ml,respectively;③The sensitivity(0.935)and specificity(0.952)of the two combinations were significantly higher than those of IL-17(0.552,0.801)and INF-γ(0.457,0.824)(P<0.05).Conclusions Serum IL-17 and INF-γThe level of PD-1 monoclonal antibody can predict and evaluate the therapeutic effect of cell cancer patients,and the combined prediction of the two has higher efficacy and significant clinical application value.