氨甲环酸辅助卡贝缩宫素预防剖宫产产妇产后出血效果及对凝血功能的影响

The Effect of Using Tranexamic Acid as An Adjuvant to Prevent Postpartum Hemorrhage in Cesarean Section Women and Its Impact on Coagulation Function

目的探讨氨甲环酸辅助卡贝缩宫素在剖宫产产妇中的应用效果。方法选择我院2021年1月—2023年10月收治的408例剖宫产产妇,按随机数字表法分为两组。对照组(204例)予以卡贝缩宫素,观察组(204例)予以氨甲环酸辅助卡贝缩宫素,两组均观察至产后24 h。对比两组出血预防效果、凝血功能、子宫复旧情况及不良反应发生情况。结果相较于对照组,观察组产后出血率较低,产后2 h、24出血量均较少(均P<0.05);治疗后相较于对照组,观察组APTT、PT水平均较低,FIB、FDP水平均较高(均P<0.05);相较于对照组,观察组子宫收缩持续时间较长,子宫底下降速度较快,恶露持续时间均较短(均P<0.05);观察组不良反应发生率与对照组相比无差异(P>0.05)。结论予以剖宫产产妇氨甲环酸辅助卡贝缩宫素治疗,可预防产后出血,减少产后出血量,改善凝血功能,促进子宫复旧,且应用安全性较好。

Objective To explore the application effect of tranexamic acid assisted cabezine oxytocin in cesarean section women.Methods A total of 408 cesarean section women admitted to our hospital from January 2021 to October 2023 were randomly divided into two groups using a random number table method.The control group(204 cases)received cabetocin,while the observation group(204 cases)received tranexamic acid assisted cabetocin.Both groups were observed until 24 hours postpartum.Compare the effectiveness of bleeding prevention,coagulation function,uterine involution,and incidence of adverse reactions between two groups.Results Compared with the control group,the observation group had a lower postpartum hemorrhage rate,with less bleeding at 2 h and 24 h postpartum(all P<0.05);after treatment,compared with the control group,the observation group's APTT and PT levels were lower,and FIB and FDP levels were higher(all P<0.05);compared with the control group,the observation group's uterine contractions lasted longer,the uterine fundus descended at a faster rate,and the duration of the malignant discharge was shorter(Both P<0.05);there was no difference in the incidence of adverse reactions in the observation group compared with the control group(P>0.05).Conclusions The use of tranexamic acid as an adjunct to cabezine oxytocin treatment for cesarean section women can prevent postpartum hemorrhage,reduce postpartum bleeding,improve coagulation function,promote uterine involution,and has good safety.