复方氟米松软膏治疗慢性泛发性湿疹的疗效

Analysis of the Efficacy of Compound Flunumi Soft Ointment in Treating Chronic Generalized Eczema

目的探索复方氟米松软膏应用于慢性泛发性湿疹患者的效果。方法在本院于2022年4月—2023年7月收治的慢性泛发性湿疹患者中随机抽取86例为对象,以随机数字表法分入观察组和对照组中,两组均给予富马酸酮替芬片+盐酸雷尼替丁胶囊+赛庚啶片口服,在此基础上,对照组43例应用卤米松/三氯生乳膏外涂治疗,观察组43例应用复方氟米松乳膏外涂治疗,均治疗4周,对比两组的治疗总有效率、血清炎症因子水平、免疫因子表达、转录因子表达、湿疹面积及严重程度指数(EASI)、不良反应发生率等。结果观察组患者的白细胞介素4(IL-4)、白细胞介素5(IL-5)、白细胞介素10(IL-10)水平、以及免疫球蛋白E(IgE)水平、嗜酸性粒细胞(EOS)计数均低于对照组(均P<0.05),且观察组的血清白细胞介素2(IL-2)水平高于对照组(P<0.05);观察组的Th1和Th2细胞所占比例低于对照组,Th1/Th2比值高于对照组(均P<0.05);观察组患者的T-bet基因表达和GATA-3基因表达均低于对照组,且T-bet/GATA-3比值高于对照组(均P<0.05);观察组治疗4周后和停药4周后的EASI评分均低于对照组(均P<0.05);观察组的治疗总有效率高于对照组(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论与卤米松/三氯生乳膏相比,复方氟米松软膏在慢性泛发性湿疹患者中应用效果肯定,更有助于缓解炎症反应和免疫反应,改善免疫功能,且用药安全性高。

Objective To explore the effect of compound application in patients with chronic generalized eczema.Methods Among the patients with chronic generalized eczema admitted to our hospital from April 2022 to July 2023,86 cases were randomly selected as subjects,and were divided into the observation group and the control group by the method of randomized numerical table,and both groups were given ketotifen fumarate tablets+ranitidine hydrochloride capsules+cyproheptadine tablets orally.On this basis,43 cases in the control group were treated with topical application of halometasone/triclosan cream,and 43 cases in the observation group were treated with topical application of compound flumethasone cream,both of them were treated for 4 weeks,and the total effective rate of treatment,serum inflammatory factor level,immune factor expression,transcription factor expression,eczema area and severity index(EASI),and incidence rate of adverse reactions of the two groups were compared.Results The levels of interleukin4(IL-4),interleukin5(IL-5),interleukin10(IL-10),immunoglobulin E(IgE)and eosinophilic granulocyte(EOS)in observation group were lower than those in control group(all P<0.05).The serum level of interleukin-2(IL-2)in observation group was higher than that in control group(P<0.05);The proportion of Th1 and Th2 cells in the observation group was lower than that in the control group,and the Th1/Th2 ratio was higher than that in the control group(both P<0.05);T-bet gene expression and GATA-3 gene expression in the patients in the observation group were lower than that in the control group,and the T-bet/GATA-3 ratio was higher than that in the control group(both P<0.05);The EASI scores of the observation group were lower than those of the control group after 4 weeks of treatment and after 4 weeks of drug cessation(both P<0.05);the total effective rate of treatment of the observation group was higher than that of the control group(P<0.05).The difference in the incidence of adverse reactions between the two groups was not statistically significant(P>0.05).Conclusions Compared with halometasone/triclosan cream,compound flumetasone ointment is more effective in relieving inflammatory reaction and immune reaction and improving immune function in patients with chronic generalized eczema,and the safety of medication is high.