2型糖尿病合并甲状腺癌患者预后的高危因素分析

Analysis of High Risk Factors for Prognosis of Type 2 Diabetes Patients with Thyroid Cancer

目的探究2型糖尿病(T2DM)合并甲状腺癌患者预后的相关因素。方法回顾性分析T2DM合并甲状腺癌患者共98例的临床资料,全部患者均行手术,术后均随访1年,统计其生存、死亡率;将生存的患者划入预后良好组,将死亡的患者划入预后不良组,并收集全部患者的年龄、性别等资料,统计影响T2DM合并甲状腺癌患者预后的相关因素。结果98例T2DM合并甲状腺癌患者中,生存75例,生存率为76.53%(75/98),死亡23例,死亡率为23.47%(23/98)。单因素分析显示:年龄、糖尿病病程、淋巴结转移、临床分期与T2DM合并甲状腺癌患者预后有关,差异有统计学意义(P<0.05);Logistic回归分析显示:年龄>60岁、糖尿病病程>5年、有淋巴结转移、Ⅲ~Ⅳ期为T2DM合并甲状腺癌患者预后不良的独立危险因素(P<0.05)。结论年龄>60岁、糖尿病病程>5年、有淋巴结转移、Ⅲ~Ⅳ期是影响T2DM合并甲状腺癌患者预后的因素,对此临床需予以高度重视。

Objective To explore the prognostic factors of type 2 diabetes mellitus(T2DM)patients with thyroid cancer.Methods A retrospective analysis was conducted on the clinical data of 98 patients with T2DM combined with thyroid cancer.All patients underwent surgery and were followed up for 1 year after surgery,and their survival and mortality rates were calculated;Assign surviving patients to a good prognosis group,and assign deceased patients to a poor prognosis group.Collect data on age,gender,and other factors that affect the prognosis of T2DM patients with thyroid cancer.Results Among the 98 T2DM patients with thyroid cancer,75 survived with a survival rate of 76.53%(75/98)and 23 died with a mortality rate of 23.47%(23/98);Univariate analysis showed that age,course of diabetes,lymph node metastasis,and clinical stage were significantly related to the prognosis of T2DM patients with thyroid cancer(P<0.05);Logistic regression analysis showed that age>60 years,duration of diabetes>5 years,lymph node metastasis,and stageⅢ~Ⅳwere independent risk factors for poor prognosis of T2DM patients with thyroid cancer(P<0.05).Conclusion Age>60 years,course of diabetes>5 years,lymph node metastasis,and stageⅢ~Ⅳare the factors that affect the prognosis of T2DM patients with thyroid cancer,which should be paid more attention to clinically.