清瘟祛毒胶囊治疗成人流行性感冒热毒袭肺证临床疗效及对炎症相关因子水平的影响

Clinical efficacy of Qingwen Qudu capsule in adults with influenza of heat-toxin attacking lung syndrome and its influence on inflammatory factors

目的观察清瘟祛毒胶囊治疗成人流行性感冒热毒袭肺证的临床疗效及对炎症相关因子水平的影响。方法选择沧州光周中医门诊部60例成人流行性感冒热毒袭肺证患者,按照随机数字表法分为2组。对照组30例予磷酸奥司他韦胶囊,治疗组30例在对照组治疗基础上加清瘟祛毒胶囊,治疗5天。比较2组临床疗效,发热、咳嗽、咽痛、乏力消失时间及病毒转阴时间。比较2组治疗前后白细胞介素6(IL-6)、IL-1β、肿瘤坏死因子α(TNF–α)、C反应蛋白(CRP)水平及咳嗽、口渴、咽痛、目赤、头痛评分。结果治疗组总有效率93.33%(28/30),高于对照组的86.67%(26/30)(P<0.05)。治疗组发热、咳嗽、咽痛、乏力消失时间及病毒转阴时间均早于对照组(P<0.05)。治疗后2组IL-6、IL-1β、TNF-α、CRP水平及咳嗽、口渴、咽痛、目赤、头痛各单项症状评分和总分均较本组治疗前显著下降(P<0.05),且治疗组较对照组更低(P<0.05)。治疗组不良反应发生率3.33%(1/30),低于对照组的16.67%(5/30)(P<0.05)。结论清瘟祛毒胶囊治疗成人流行性感冒热毒袭肺证可缩短发热、咽痛等症状消失的时间及病毒转阴时间,改善临床症状,降低炎症相关因子水平,疗效确切。

Objective To observe the clinical efficacy of Qingwen Qudu capsule in adults with influenza of heat-toxin attacking lung syndrome and its influence on inflammatory factors.Methods Sixty adults with influenza(heat-toxin attacking lung syndrome)who were treated at Guangzhou TCM Clinic were randomly assigned into treatment group(n=30)and control group(n=30).All patients were managed by oseltamivir phosphate capsules,and those in treatment group were additionally treated with Qingwen Qudu capsule.Treated for 5 days,the aim was to compare disappearing time(fever,cough,sore throat,fatigue)and virus turning negative time,inflammation-related factors(interleukin-6[IL-6],IL-1β,tumor necrosis factor alpha[TNF–α],C-reactive protein[CRP]),and the symptom scores(cough,thirst,sore throat,red eyes,headache).The curative effect was assessed.Results The overall effective rate in the treatment group was better than that in the control group(93.33%[28/30]vs 86.67%[26/30],P<0.05,respectively).The disappearing time(fever,cough,sore throat,fatigue)and the virus turning negative time were significantly shorter in the treatment group than those of the control group(P<0.05).After treatment,the levels of IL-6,IL-1β,TNF-α,CRP were significantly decreased in both groups,but the symptom scores(cough,thirst,sore throat,red eyes,headache and the total scores)were significantly decreased(all P<0.05),the improvements were more pronounced in the treatment group relative to the control group(all P<0.05).The incidence of adverse reactions in the treatment group was significantly lower than that of the control group(3.33%[1/30]vs 16.67%[5/30],P<0.05).Conclusion Qingwen Qudu capsule has a definite curative effect in adults with influenza(heat-toxin attacking lung syndrome),which can shorten the disappearing time(fever,sore throat,etc.)and the virus turning negative time,improve clinical symptoms scores,reduce the level of inflammation-related factors.