健脾温中益气方联合针灸对结直肠癌术后患者胃肠道功能及胃肠道激素水平的影响

Effects of Jianpi Wenzhong Yiqi Formula combined with acupuncture and moxibustion on postoperative gastrointestinal function and gastrointestinal hormone levels in patients with colorectal cancer

目的观察健脾温中益气方联合针灸对结直肠癌术后患者胃肠道功能及胃肠道激素水平的影响。方法将102例结直肠癌术后患者按照随机数字表法分为2组,对照组51例予西医常规治疗,治疗组51例在对照组治疗基础上加用健脾温中益气方联合针灸治疗,2组均治疗30天。比较2组胃肠功能、胃肠道激素水平、免疫功能指标变化;比较2组不良反应。结果治疗组首次排气时间、首次排便时间及肠鸣音恢复时间均较对照组短(P<0.05)。2组治疗后胃动素、胃泌素水平均较本组治疗前降低(P<0.05),治疗后治疗组胃动素、胃泌素水平均高于对照组(P<0.05)。2组治疗后CD8^(+)较本组治疗前降低(P<0.05),CD4^(+)、CD3^(+)较本组治疗前升高(P<0.05);治疗后治疗组CD8^(+)低于对照组(P<0.05),CD4^(+)、CD3^(+)高于对照组(P<0.05)。2组不良反应总发生率比较差异无统计学意义(P>0.05)。结论健脾温中益气方联合针灸治疗可改善结直肠癌术后患者胃肠道功能和胃肠道激素水平,提高机体免疫功能,安全性较高。

Objective To investigate the effects of Jianpi Wenzhong Yiqi Formula combined with acupuncture and moxibustion on postoperative gastrointestinal function and gastrointestinal hormone levels in patients with colorectal cancer(CC).Methods A total of 102 CC patients were assinged into treatment group(n=51)and control group(n=51)using the random number table.All patients were treated with routine Western medicine,and those in the treatment group were additionally treated with Jianpi Wenzhong Yiqi Formula combined with acupuncture and moxibustion.Treated for 30 days,the changes in gastrointestinal function,gastrointestinal hormones level,immune function and adverse reactions of the two groups were including as comparators.Results After treatment,the recovery time of first exhaust and defecation,grade bowel sounds in the treatment group was significantly less than that of the control group(P<0.05).The levels of motilin and gastrin in the both groups were significantly decreased than those before treatment(P<0.05),and which were more pronounced in the treatment group(P<0.05).Significantly lower CD8^(+),and significantly higher CD4^(+)and CD3^(+)were detected in both groups(P<0.05),and the treatment group was surperior to the control group for the levels of CD8^(+),and CD4^(+),CD3^(+)(P<0.05).The total incidence of adverse reactions in both groups were similar(P>0.05).Conclusion Jianpi Wenzhong Yiqi Formula combined with acupuncture and moxibustion can improve postoperative gastrointestinal function and gastrointestinal hormone levels in CC patients,which is capable enhancing immune function,moreover,it has high safety and good overall effect.