氧化苦参碱治疗过敏性皮肤病作用机制的研究进展

Research progress on mechanism of oxymatrine in treatment of allergic skin diseases

过敏性皮肤病具有慢性、复发性特点,需长期接受药物治疗,但可引起不同程度不良反应,且停药后症状易复发。氧化苦参碱是苦参、槐花中主要活性成分,通过抑制肥大细胞活化、调节淋巴细胞增殖、调节Th1/Th2的平衡、调节辅助T细胞17/调节T细胞平衡、调节细胞因子信号传导抑制因子1的表达、下调瞬时受体电位通道蛋白A1和瞬时受体电位通道蛋白V1的表达、抑制丝裂原活化蛋白激酶/蛋白激酶B信号通路激活多途径多靶点防治过敏性皮肤病。综述了氧化苦参碱治疗过敏性皮肤病的作用机制,为氧化苦参碱的临床使用提供依据。

Allergic skin diseases have chronic and recurrent characteristics,and patients need long-term treatment,but can cause varying degrees of adverse reactions,and symptoms are prone to recurrence after discontinuation of medication.Oxymatrine is the main active ingredient in Sophorae Flavescentis Radix and Sophorae Flos.Oxymatrine can prevent and treat allergic skin diseases through multiple pathways and targets through inhibiting mast cell activation,regulating lymphocyte proliferation,regulating Th1/Th2 balance,regulating Th17/Treg balance,regulating the expression of cytokine signaling inhibitory factor 1,down-regulating the expression of TRPA1 and TRPV1,and inhibiting the activation of MAPK/Akt signaling pathway.This article reviews the mechanism of action of oxymatrine in treatment of allergic skin diseases,providing a basis for the clinical use of oxymatrine.