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间歇性θ短阵脉冲刺激对酒精依赖患者的疗效

Efficacy of intermittent theta burst stimulation in the treatment of patients with alcohol dependence
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摘要 目的探讨间歇性θ短阵脉冲刺激(iTBS)对酒精依赖患者的治疗效果。方法96例酒精依赖患者随机分为试验组和对照组,每组48例。两组在给予地西泮替代治疗和常规对症支持治疗基础上,试验组和对照组分别给予左侧背外侧前额叶皮质iTBS和伪刺激。于治疗前及治疗后4、12周时,采用VAS和宾夕法尼亚酒精渴求量表(PACS)评分评估患者对酒精渴求程度,贝克抑郁量表(BDI)和贝克焦虑量表(BAI)评分分别评估患者的抑郁和焦虑情绪,停止信号反应时间(SSRT)评价患者的反应抑制能力,并于出院后4、12周时随访患者的复饮情况。结果与治疗前相比,两组治疗后4、12周时VAS、PACS、BDI、BAI评分及SSRT均减少(P<0.05);试验组治疗后4、12周时VAS、PACS、BDI、BAI评分及SSRT均少于对照组(P<0.05)。试验组出院后12周时患者复饮率低于对照组(4.17%vs.10.42%)(P<0.05)。结论iTBS治疗能够有效改善酒精依赖患者的负性情绪、酒精渴求程度和反应抑制能力,并降低复饮率。 Objective To explore the clinical effect of intermittent theta burst stimulation(iTBS)on the patients with alcohol dependence.Methods A total of 96 patients with alcohol dependence were randomly divided into two groups of A and B with 48 cases each.On the basis of diazepam replacement therapy and conventional symptomatic and supportive therapy,the patients in groups of A and B were accepted iTBS and pseudo-stimulation of left dorsolateral prefrontal cortex,respectively.The degree of alcohol craving was assessed by VAS and Penn Alcohol Craving Scale(PACS)scores before treatment and at 4 and 12 weeks after treatment.The depression and anxiety were evaluated by Beck depression inventory(BDI)and Beck anxiety inventory(BAI)scores,respectively.The ability of response inhibition was analyzed by stop signal reaction time(SSRT).The redrinking was followed up at 4 and 12 weeks after discharge.Results Compared with before treatment,the VAS,PACS,BDI and BAI scores and SSRT were decreased at 4 and 12 weeks after treatment in both groups(P<0.05).The VAS,PACS,BDI and BAI scores and SSRT at 4 and 12 weeks after treatment in group A were less than those in group B(P<0.05).The redrinking rate at 12 weeks after discharge in group A was lower than that in group B(4.17%vs.10.42%)(P<0.05).Conclusion iTBS can effectively improve the negative emotion,degree of alcohol craving and ability of response inhibition,and reduce the redrinking rate of the patients with alcohol dependence.
作者 郑高健 庞军委 姚潇妮 唐旭 许学明 ZHENG Gaojian;PANG Junwei;YAO Xiaoni(Department of Substance Dependence,Taizhou Second People's Hospital,Taizhou 317200,CHINA)
出处 《江苏医药》 CAS 2024年第5期451-454,共4页 Jiangsu Medical Journal
基金 浙江省医药卫生科技计划项目(2019KY780) 台州市科技局科技项目(22ywb74)。
关键词 酒精依赖 间歇性θ短阵脉冲刺激 焦虑 抑郁 Alcohol dependence Intermittent theta burst stimulation Anxiety Depression
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