Genetic testing and prenatal diagnosis of 64 pedigrees with autosomal dominant polycystic kidney disease

Objective To detect and analyze the gene variation types of 64 unrelated pedigrees affected with autosomal dominant polycystic kidney disease (ADPKD),and explore the detection efficiency of multiple gene analysis techniques and variation characteristics.Methods The clinical data of 64 pedigrees with ADPKD from Nephrology Department or Genetic and Prenatal Diagnosis Center of the First Affiliated Hospital of Zhengzhou University from December 2017 to August 2020 were retrospectively analyzed.